General Information of This Photoreceptor (PR)
PR ID PR00082
PR Name LOV2 domain of Avena sativa Phototropin 1 (AsLOV2)
Source of Species Avena sativa
Class LOV domain
UniProt ID O49003
GenBank 162330142
PDB ID 2V1A
Sequence
LATTLERIEKNFVITDPRLPDNPIIFASDSFLQLTEYSREEILGRNCRFLQGPETDRATV
RKIRDAIDNQTEVTVQLINYTKSGKKFWNLFHLQPMRDQKGDVQYFIGVQLDGTEHVRDA
AEREGVMLIKKTAENIDEAAKEL
Components Photoreceptor LOV2 domain of Avena sativa Phototropin 1 (AsLOV2)
Cofactor Flavin mononucleotide (FMN)
Detail Info
3D Structure
Click to Save PDB File
Cofactor Detail of This PR
Cofactor Name Flavin mononucleotide (FMN)
PubChem CID 643976
Structure
Formula C17H21N4O9P
Molecular Weight 456.3
Optogenetic System (OS) Consisting of This PR
OS00170
OS Info
OS Name: Blue light-inducible degradation domain (B-LID)
[1]
Fusion protein: Degradation peptide
OS00152
OS Info
OS Name: Blue-lightCinduced K+ channel 1 (BLINK 1)
[2]
Fusion protein: Potassium channel protein kcv
OS00165
OS Info
OS Name: Bue light-inducible nuclear export system (LEXY)
[3]
Functional protein: LOV2 domain of Avena sativa Phototropin 1
Fusion protein: Nuclear export sequence
OS00713
OS Info
OS Name: Bue light-inducible nuclear export system 1 (LEXY 1)
[4]
Functional protein: LOV2 domain of Avena sativa Phototropin 1
OS00714
OS Info
OS Name: Bue light-inducible nuclear export system 2 (LEXY 2)
[4]
Fusion protein: Low molecular weight phosphotyrosine protein phosphatase
OS00715
OS Info
OS Name: Bue light-inducible nuclear export system 3 (LEXY 3)
[4]
Fusion protein: NTF2-related export protein 1
OS00716
OS Info
OS Name: Bue light-inducible nuclear export system 4 (LEXY 4)
[4]
Fusion protein: Activation domain
OS00164
OS Info
OS Name: Bue light-inducible nuclear import system (LINuS)
[3]
Functional protein: LOV2 domain of Avena sativa Phototropin 1
OS00171
OS Info
OS Name: Circularly permuted LOV inhibitor of protein synthesis 1 (CLIPS 1)
[5]
Fusion protein: Eukaryotic initiation factor 4E binding protein 2
OS00172
OS Info
OS Name: Circularly permuted LOV inhibitor of protein synthesis 2 (CLIPS 2)
[5]
Fusion protein: CRISPR-associated endonuclease Cas9
OS00153
OS Info
OS Name: Control G-protein signal by LOV2 system (LOV2GIVe)
[6]
Fusion protein: Girdin
OS00669
OS Info
OS Name: Light-Controlled p21 Applying the LINuS System (LINuS)
[7]
Fusion protein: CDK-interacting protein p21 (CDKN1A)-nuclear localization signal (Arg 140, Lys 141 and Arg 142 replaced by Ala)
OS00163
OS Info
OS Name: Light-inducible Cre recombinase (LiCre)
[8]
Fusion protein: CreN means N terminal of Cre recombinase and CreC means C terminal of Cre recombinase
OS00688
OS Info
OS Name: Light-responsive RNA-protein nanowires (LRNA)
[9]
Functional protein: LOV2 domain of Avena sativa Phototropin 1
Recruited protein: Zdark
OS00708
OS Info
OS Name: LOV-Turbo precise spatiotemporal controling of proximity labeling (LOV-Turbo)
[10]
Fusion protein: TurboID (T52S; L73Q; I147T; A166V; I231V; F286L)
OS00687
OS Info
OS Name: MPP8-LAMS, MPP8-based light-activated modification sensor (MPP8-LAMS)
[11]
Fusion protein: H3K9me3-binding reader domain of the human M phase phosphoprotein 8
OS00637
OS Info
OS Name: MyLOVChar (MyLOVChar)
[12]
Functional protein: Myosin
OS00166
OS Info
OS Name: Optogenetic control protein-protein interaction system 3 (Opto-PPI 3)
[13]
Fusion protein: Binder of cPYP-light state
OS00167
OS Info
OS Name: Optogenetic control protein-protein interaction system 4 (Opto-PPI 4)
[13]
Recruited protein: Binder of AsLOV2-dark state
Functional protein: LOV2 domain of Avena sativa Phototropin 1
OS00159
OS Info
OS Name: Optogenetic JNK inhibit system 1 (OptoJNKi 1)
[14]
Fusion protein: Minimal JNK-binding protein 1
OS00156
OS Info
OS Name: Optogenetic LaG9 (OptoLaG9)
[15]
Fusion protein: A anti-EGFP nanobody
OS00157
OS Info
OS Name: Optogenetic LaM4 (OptoLaM4)
[15]
Fusion protein: A anti-mCherry nanobody
OS00155
OS Info
OS Name: Optogenetic LaM8 (OptoLaM8)
[15]
Fusion protein: A anti-mCherry nanobody
OS00168
OS Info
OS Name: Optogenetic modulation of REST target gene system 1 (Opto-REST 1)
[16]
Fusion protein: Paired amphipathic helix 1
OS00169
OS Info
OS Name: Optogenetic modulation of REST target gene system 2 (Opto-REST 2)
[16]
Fusion protein: First N-terminal of REST interacting LIM domain protein
OS00160
OS Info
OS Name: Optogenetic p38MAPK inhibit system 1 (Optop38i 1)
[14]
Fusion protein: Putative p38MAPK inhibitor
OS00161
OS Info
OS Name: Optogenetic p38MAPK inhibit system 2 (Optop38i 2)
[14]
Fusion protein: Putative p38MAPK inhibitor
OS00162
OS Info
OS Name: Optogenetic p38MAPK inhibit system 3 (Optop38i 3)
[14]
Fusion protein: Putative p38MAPK inhibitor
OS00154
OS Info
OS Name: Optogenetic regulate SOAR function system (OptoSOAR)
[17]
Fusion protein: STIM-Orai activating region
OS00695
OS Info
OS Name: Optogenetic YAP (optoYAP)
[18] , []
Fusion protein: Yes-associated protein
OS00696
OS Info
OS Name: Optogenetic YAP S127A (optoYAP S127A)
[18] , []
Fusion protein: Yes-associated protein (S127A)
OS00158
OS Info
OS Name: Optogentic HA4 (OptoHA4)
[19]
Fusion protein: A monobody
OS00700
OS Info
OS Name: Photoactivatable targeted protein degradation system (paProtacL-Survivin)
[20]
Functional protein: LOV2 domain of Avena sativa Phototropin 1
References
1 Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells
2 Optogenetics. Engineering of a light-gated potassium channel
3 Optogenetic Control of Nucleocytoplasmic Protein Transport
4 Analysis of Slow-Cycling Variants of the Light-Inducible Nuclear Protein Export System LEXY in Mammalian Cells
5 A Yeast System for Discovering Optogenetic Inhibitors of Eukaryotic Translation Initiation
6 Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein
7 Cell Cycle Control by Optogenetically Regulated Cell Cycle Inhibitor Protein p21
8 A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch
9 Engineer RNA-Protein Nanowires as Light-Responsive Biomaterials
10 Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells
11 Optogenetics for sensors: On-demand fluorescent labeling of histone epigenetics
12 Optical control of fast and processive engineered myosins in vitro and in living cells
13 Discovering Selective Binders for Photoswitchable Proteins Using Phage Display
14 A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs
15 Optogenetic control of protein binding using light-switchable nanobodies
16 Regulation of neural gene transcription by optogenetic inhibition of the RE1-silencing transcription factor
17 Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
18 Optogenetic control of YAP can enhance the rate of wound healing
19 Development of light-responsive protein binding in the monobody non-immunoglobulin scaffold
20 Split-Cas9-based targeted gene editing and nanobody-mediated proteolysis-targeting chimeras optogenetically coordinated regulation of Survivin to control the fate of cancer cells