| General Information of This Controlled Protein (CP) |
| CP ID |
CP00373
|
| CP Name |
First N-terminal of REST interacting LIM domain protein (RILP-N313) |
| CP Type |
Fusion protein
|
| Common Name |
Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1)
|
| Organism |
Homo sapiens (Human)
|
| UniProt ID |
Q96MT3
|
| UniProt Entry |
PRIC1_HUMAN
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| KEGG |
hsa:144165
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| Function |
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
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| Sequence |
MPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYV
NSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRA
MMHAVCEQCGLQMNGGEVAVFASRAGPGVCWRPSCFVCFTCNELLVDLIYFYQDGKIHCG
RHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCC
GCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQI
YCSKTCSLGEDIH
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