Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00539
CP Name Yes-associated protein (YAP)
CP Type Fusion protein
Common Name Transcriptional coactivator YAP1
Organism Gallus gallus (Chicken)
UniProt ID P46936
UniProt Entry YAP1_CHICK
KEGG gga:396171
Function Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity).
Sequence
MDPGQPQPQQPPQAAQPPAPQQAAPQPPGAGSGAPGGAAQPPGAGPPPAGHQIVHVRGDS
ETDLEALFNAVMNPKGANVPHTLPMRLRKLPDSFFKPPEPKAHSRQASTDAGTAGALTPQ
HVRAHSSPASLQLGAVSPGTLTPSGVVTGPGAPSSQHLRQSSFEIPDDVPLPPGWEMAKT
PSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNLMNSASAMNQRISQSAPVK
QPPPLAPQSPQGGVMGGSSSNQQQQMRLQQLQMEKERLRLKHQELLRQELALRSQLPTME
QDGGSQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDF
LNSVDEMDTGDSISQSNIPSHQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQE
ALSSDILNDMESVLAATKPDKESFLTWL
Optogenetic System (OS) Controlling This CP
OS00695
OS Info
OS Name
Optogenetic YAP
[1], []
Photoreceptor (PR) Name
LOV2 domain of Avena sativa Phototropin 1 (AsLOV2)
PR Info
Components
Photoreceptor
LOV2 domain of Avena sativa Phototropin 1 (AsLOV2)
Cofactor
Flavin mononucleotide (FMN)
References
1 Optogenetic control of YAP can enhance the rate of wound healing