Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00305
CP Name CreN means N terminal of Cre recombinase and CreC means C terminal of Cre recombinase (Cre)
CP Type Fusion protein
Common Name Recombinase cre
Organism Escherichia phage P1 (Bacteriophage P1)
UniProt ID P06956
UniProt Entry RECR_BPP1
KEGG vg:2777477
Function Catalyzes site-specific recombination between two 34-base-pair LOXP sites. Its role is to maintain the phage genome as a monomeric unit-copy plasmid in the lysogenic state.
Sequence
MSNLLTVHQNLPALPVDATSDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNN
RKWFPAEPEDVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRRI
RKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAYNTLLRIAEIARI
RVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVTKLVERWISVSGVADDPNNYLFC
RVRKNGVAAPSATSQLSTRALEGIFEATHRLIYGAKDDSGQRYLAWSGHSARVGAARDMA
RAGVSIPEIMQAGGWTNVNIVMNYIRNLDSETGAMVRLLEDGD
Optogenetic System (OS) Controlling This CP
OS00055
OS Info
OS Name
Brainbow-based live imaging system
[1]
Photoreceptor (PR) Name
Cryptochrome 2 (CRY2)
PR Info
Components
Photoreceptor
Cryptochrome 2 (CRY2)
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00720
OS Info
OS Name
Bue light-inducible nuclear export system - i 4
[2]
Photoreceptor (PR) Name
LOV2 domain of Avena sativa Phototropin 1 (V416I) (AsLOV2 (V416I))
PR Info
Components
Photoreceptor
LOV2 domain of Avena sativa Phototropin 1 (V416I) (AsLOV2 (V416I))
Cofactor
Flavin mononucleotide (FMN)
OS00724
OS Info
OS Name
Bue light-inducible nuclear export system - s 4
[2]
Photoreceptor (PR) Name
LOV2 domain of Avena sativa Phototropin 1 (V416L) (AsLOV2 (V416L))
PR Info
Components
Photoreceptor
LOV2 domain of Avena sativa Phototropin 1 (V416L) (AsLOV2 (V416L))
Cofactor
Flavin mononucleotide (FMN)
OS00163
OS Info
OS Name
Light-inducible Cre recombinase
[3]
Photoreceptor (PR) Name
LOV2 domain of Avena sativa Phototropin 1 (AsLOV2)
PR Info
Components
Photoreceptor
LOV2 domain of Avena sativa Phototropin 1 (AsLOV2)
Cofactor
Flavin mononucleotide (FMN)
OS00151
OS Info
OS Name
Optogenetic control Recombinase Cre by VVD system
[4]
Photoreceptor (PR) Name
Vivid PAS domain (VVD)
PR Info
Components
Photoreceptor
Vivid PAS domain (VVD)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00279
OS Info
OS Name
Photoactivatable split-Cre recombinase optogenetic system
[5]
Photoreceptor (PR) Name
Negative Magnet (nMag)
PR Info
Components
Photoreceptor
Negative Magnet (nMag)
Complementary Protein
Positive Magnet (pMag)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00068
OS Info
OS Name
Second-generation photoactivatable Cre recombinase
[6]
Photoreceptor (PR) Name
Photolyase homology region of Cryptochromes 2 (L348F) (CRY2PHR (L348F))
PR Info
Components
Photoreceptor
Photolyase homology region of Cryptochromes 2 (L348F) (CRY2PHR (L348F))
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00278
OS Info
OS Name
Tamoxifen-gated photoactivatable split-Cre recombinase optogenetic system
[7]
Photoreceptor (PR) Name
Negative Magnet (nMag)
PR Info
Components
Photoreceptor
Negative Magnet (nMag)
Complementary Protein
Positive Magnet (pMag)
Cofactor
Flavin adenine dinucleotide (FAD)
References
1 Live imaging of multicolor-labeled cells in Drosophila
2 Analysis of Slow-Cycling Variants of the Light-Inducible Nuclear Protein Export System LEXY in Mammalian Cells
3 A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch
4 Light-Inducible Recombinases for Bacterial Optogenetics
5 A photoactivatable Cre-loxP recombination system for optogenetic genome engineering
6 Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase
7 An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics