General Information of This Controlled Protein (CP)
CP ID CP00102
CP Name Channelrhodopsin 2 (ChR2)
CP Type Functional protein
Common Name Archaeal-type opsin 2 (Chlamyopsin 4 light-gated ion channel) (Retinal binding protein) (Sensory opsin B)
Organism Chlamydomonas reinhardtii (Chlamydomonas smithii)
UniProt ID Q8RUT8
UniProt Entry Q8RUT8_CHLRE
KEGG cre:CHLRE_02g085257v5
Sequence
MDYGGALSAVGRELLFVTNPVVVNGSVLVPEDQCYCAGWIESRGTNGAQTASNVLQWLAA
GFSILLLMFYAYQTWKSTCGWEEIYVCAIEMVKVILEFFFEFKNPSMLYLATGHRVQWLR
YAEWLLTCPVILIHLSNLTGLSNDYSRRTMGLLVSDIGTIVWGATSAMATGYVKVIFFCL
GLCYGANTFFHAAKAYIEGYHTVPKGRCRQVVTGMAWLFFVSWGMFPILFILGPEGFGVL
SVYGSTVGHTIIDLMSKNCWGLLGHYLRVLIHEHILIHGDIRKTTKLNIGGTEIEVETLV
EDEAEAGAVNKGTGK
Optogenetic System (OS) Controlling This CP
OS00302
OS Info
OS Name
Design Channelrhodopsin 2 for ultrafast optogenetic control system 1
[1]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00303
OS Info
OS Name
Dural opsin controled neural signal system
[2]
Photoreceptor (PR) Name
PR Info
Components
Photoreceptor
OS00293
OS Info
OS Name
EYFP tag Channelrhodopsin2 for neuron signal regulation system 1
[3], [4], [5], [6]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00296
OS Info
OS Name
MCh tag Channelrhodopsin2 for neuron signal regulation system 1
[7], [8]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00297
OS Info
OS Name
MCh tag Channelrhodopsin2 for neuron signal regulation system 2
[9], [10]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00294
OS Info
OS Name
Optogenetic activation brown adipose tissue for sympathetic neuromodulation 1
[11]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00734
OS Info
OS Name
Optogenetic activation of axons system
[12]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00705
OS Info
OS Name
Optogenetic controling ventromedial orbitofrontal cortex system 1
[13], [14]
Photoreceptor (PR) Name
Cryptochrome 2 (CRY2)
PR Info
Components
Photoreceptor
Cryptochrome 2 (CRY2)
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00300
OS Info
OS Name
Optogenetic neuromodulation for inflammation regulation system
[15]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00301
OS Info
OS Name
Optogenetic regulate cardiomyocytes system 1
[16]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00299
OS Info
OS Name
Optogenetic regulate postsynaptic potentials in the pharyngeal system
[17]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00298
OS Info
OS Name
Optogenetic regulate retinal ganglion cell for vison form system
[18]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00295
OS Info
OS Name
Optogenetic regulation VTA dlutamate neuron system
[19]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00610
OS Info
OS Name
Optogenetic stimulate Vglut2-positive neurons for Parkinson's Disease treatment system
[20]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00707
OS Info
OS Name
Optogenetic system of peripheral somatosensory neurons
[21]
Photoreceptor (PR) Name
Channelrhodopsin 2 (ChR2)
PR Info
Components
Photoreceptor
Channelrhodopsin 2 (ChR2)
Cofactor
All-trans-Retinal (Trans-Retinal)
OS00304
OS Info
OS Name
White light sensetive opsin for visual restoration system
[22]
Photoreceptor (PR) Name
PR Info
Components
Photoreceptor
References
1 Ultrafast optogenetic control
2 Informational lesions: optical perturbation of spike timing and neural synchrony via microbial opsin gene fusions
3 Optogenetic control of insulin secretion by pancreatic -cells in vitro and in vivo
4 Median raphe serotonin neurons promote anxiety-like behavior via inputs to the dorsal hippocampus
5 Lost in translation: no effect of repeated optogenetic cortico-striatal stimulation on compulsivity in rats
6 Reorganization of Thalamic Inputs to Lesioned Cortex Following Experimental Traumatic Brain Injury
7 Neural substrates of awakening probed with optogenetic control of hypocretin neurons
8 Driving fast-spiking cells induces gamma rhythm and controls sensory responses
9 Optical deconstruction of parkinsonian neural circuitry
10 An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology
11 Optogenetic-induced sympathetic neuromodulation of brown adipose tissue thermogenesis
12 A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus
13 Postnatal Phencyclidine-Induced Deficits in Decision Making Are Ameliorated by Optogenetic Inhibition of Ventromedial Orbitofrontal Cortical Glutamate Neurons
14 The Translational Utility of Circuit-Based Manipulations in Preclinical Models
15 Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
16 Optogenetic modulation of cardiac action potential properties may prevent arrhythmogenesis in short and long QT syndromes
17 A comparison of electrically evoked and channel rhodopsin-evoked postsynaptic potentials in the pharyngeal system of Caenorhabditis elegans
18 Visual properties of transgenic rats harboring the channelrhodopsin-2 gene regulated by the thy-1.2 promoter
19 Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus
20 Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease
21 Optogenetic Activation of Peripheral Somatosensory Neurons in Transgenic Mice as a Neuropathic Pain Model for Assessing the Therapeutic Efficacy of Analgesics
22 Broad-Band Activatable White-Opsin