Details of the Optogenetic System
| General Information of This Optogenetic System (OS) | ||||||
|---|---|---|---|---|---|---|
| OS ID |
OS00298
|
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| OS Name |
Optogenetic regulate retinal ganglion cell for vison form system
(Opto-RGCs-VF)
|
[1] | ||||
|
Photoreceptor (PR) |
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| Cofactor | All-trans-Retinal (Trans-Retinal) | |||||
| Controlled Protein | Functional protein | Channelrhodopsin 2 | ||||
| OS Application Information (1) | ||||||
|---|---|---|---|---|---|---|
| Mechanism of Action | Ion channel open | [ 1] | ||||
| Controlled Signal Pathway | Visual formation | |||||
| Effect | Activation | |||||
| Application | ChR2-expressing RGCs are subsutable for rod photoreceptor cells in the retina to restore vision | |||||
| Note | Only sensitive to blue light | |||||
| Current Intensity | 150 pA | |||||
| Channel Type | Cation channel | |||||
| Light Information | Activation Wavelength | 470 nm | ||||
| Activation Time | 10-100 ms | |||||
| Light Intensity | 3.7 ± 2.3 microwatts per square millimeter | |||||
| Expression Information | Expression Method | Transgene | ||||
| Cell Lines | Retinal ganglion cells | |||||