Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00141
PR Name Volvox channelrhodopsin 1 (VChR1)
Source of Species volvox
Class Opsin
UniProt ID B4Y103
GenBank 167650744
Sequence
MDYPVARSLIVRYPTDLGNGTVCMPRGQCYCEGWLRSRGTSIEKTIAITLQWVVFALSVA
CLGWYAYQAWRATCGWEEVYVALIEMMKSIIEAFHEFDSPATLWLSSGNGVVWMRYGEWL
LTCPVLLIHLSNLTGLKDDYSKRTMGLLVSDVGCIVWGATSAMCTGWTKILFFLISLSYG
MYTYFHAAKVYIEAFHTVPKGICRELVRVMAWTFFVAWGMFPVLFLLGTEGFGHISPYGS
AIGHSILDLIAKNMWGVLGNYLRVKIHEHILLYGDIRKKQKITIAGQEMEVETLVAEEED
DTVKQSTAKYASRDSFITMRNRMREKGLEVRASLDAGGGDSGMEAGGGGAAHAQPHMAKP
GTELGKTMSASFTNGAATSLEPGRVILAVPDISMVDFFREQFAQLPVPYEVVPALGAENT
VQLVQQAAMLGGCDFVLMHPEFLRDRGPTGLLPQVKMMGQRTAAFGWSQMGPMRDLIESS
GVGAWLEGPSFGSGISQAALQQLVVKMQQAKRMAAMGSMMGGGMGNGMGMGMGMGMGMGM
GNGMGNGMGMGNGMGNGMGMGNGMGNGMGMGNGMGMGNGMGMGNGMGMGNGMGNGMGNGM
GMGNGMGNGMGNGMGNGMGNGMGNGMGMGNGMGMGNGMGNGMGNGMGNGMGNGMGMMTPG
AMGMGMGGMGNLAAAAGNAMYGGGGGGGGSTMGSGNAAMMTGLVMGGGNGVGAGPGGVVA
NLGSSALQPQSQMMGGGNVVGMSSPQLQLQQSSSMPLGGLAPNRIGNNPLFGAAPSPLHS
QPGASPTGLSSPQLGMGAMLPAGTSVGAGGGSVGPTETDMLQQLMTEINRLKDELGE
Components Photoreceptor Volvox channelrhodopsin 1 (VChR1)
Cofactor All-trans-Retinal (Trans-Retinal)
Detail Info
3D Structure
Click to Save PDB File
Cofactor Detail of This PR
Cofactor Name All-trans-Retinal (Trans-Retinal)
PubChem CID 638015
Structure
Formula C20H28O
Molecular Weight 284.4
Optogenetic System (OS) Consisting of This PR
OS00307
OS Info
OS Name: Enhenced iteration of the excitory liminopsin LMO3 (ELMO3)
[1]
Functional protein: Volvox channelrhodopsin-1
Detail Info
OS00312
OS Info
OS Name: Luminopsin 3 induced pluripotent stem cell-derived neural progenitor cells system (LMO3-iPS-NPC)
[2]
Functional protein: Volvox channelrhodopsin-1
Detail Info
OS00306
OS Info
OS Name: Luminopsin 3 system (LMO3)
[3] , [] , []
Functional protein: Volvox channelrhodopsin-1
Detail Info
OS00311
OS Info
OS Name: Optogenetic activate neuron by LMO 3 system (Opto-AN-LMO3)
[4]
Functional protein: Volvox channelrhodopsin-1
Detail Info
OS00305
OS Info
OS Name: Optogenetic control opsin activity by luciferase 1 (Opto-LF1)
[5]
Functional protein: Volvox channelrhodopsin-1
Detail Info
OS00308
OS Info
OS Name: Optogenetic fast neural control system (OptoFNC)
[6]
Functional protein: Volvox channelrhodopsin-1
Detail Info
OS00309
OS Info
OS Name: Optogenetic investigate the cellular E/I balance hypothesis in freely moving mammals (Opto-EIB-FMM)
[7]
Functional protein: Volvox channelrhodopsin-1
Detail Info
OS00310
OS Info
OS Name: Optogenetic visual restoration system 1 (Opto-VR 1)
[8]
Functional protein: Volvox channelrhodopsin-1
Detail Info
References
1 Improved trafficking and expression of luminopsins for more efficient optical and pharmacological control of neuronal activity
2 Optochemogenetic Stimulation of Transplanted iPS-NPCs Enhances Neuronal Repair and Functional Recovery after Ischemic Stroke
3 Bioluminescence-driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model
4 Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation
5 Novel luciferase-opsin combinations for improved luminopsins
6 Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri
7 Neocortical excitation/inhibition balance in information processing and social dysfunction
8 Restoration of the majority of the visual spectrum by using modified Volvox channelrhodopsin-1