Details of the Optogenetic System
| General Information of This Optogenetic System (OS) | ||||||
|---|---|---|---|---|---|---|
| OS ID |
OS00310
|
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| OS Name |
Optogenetic visual restoration system 1
(Opto-VR 1)
|
[1] | ||||
|
Photoreceptor (PR) |
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| Cofactor | All-trans-Retinal (Trans-Retinal) | |||||
| Controlled Protein | Functional protein | Volvox channelrhodopsin-1 | ||||
| OS Application Information (1) | ||||||
|---|---|---|---|---|---|---|
| Mechanism of Action | Ion channel open | [ 1] | ||||
| Controlled Signal Pathway | Visual formation | |||||
| Effect | Activation | |||||
| Application | Use modified Volvox channelrhodopsin-1 (mVChR1) for visual recovery | |||||
| Note | Experimental control | |||||
| Current Intensity | 18.4 ± 22.3 pA | |||||
| Channel Type | Cation channel | |||||
| Light Information | Activation Wavelength | 450 ± 25 nm | ||||
| Activation Time | Seconds | |||||
| Light Intensity | 0.85-2.15 milliwatts per square miliimeter | |||||
| Expression Information | Expression Method | Transduction | ||||
| Cell Lines | Retinal ganglion cells | |||||