Details of the Optogenetic System
| General Information of This Optogenetic System (OS) | ||||||
|---|---|---|---|---|---|---|
| OS ID |
OS00306
|
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| OS Name |
Luminopsin 3 system
(LMO3)
|
[1], [], [] | ||||
|
Photoreceptor (PR) |
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| Cofactor | All-trans-Retinal (Trans-Retinal) | |||||
| Controlled Protein | Functional protein | Volvox channelrhodopsin-1 | ||||
| OS Application Information (1) | ||||||
|---|---|---|---|---|---|---|
| Mechanism of Action | Ion channel open | [ 1] , [ ] , [ ] | ||||
| Controlled Signal Pathway | Cell differentiate | |||||
| Effect | Activation | |||||
| Application | Bioluminesce-driven activation of transplanted neural precursor cells improves motor deficits in PD disease mouse | |||||
| Note | Stimulation of transplanted cells for a short period of time resulted in measurable improvement of motor behavior | |||||
| Channel Type | Cation channel | |||||
| Light Information | Activation Wavelength | Blue or CTZ luminescenece | ||||
| Expression Information | Expression Method | Transplantation and Transfection | ||||
| Cell Lines | Human neural stem cells | |||||