Details of the Optogenetic System
| General Information of This Optogenetic System (OS) | ||||||
|---|---|---|---|---|---|---|
| OS ID |
OS00309
|
|||||
| OS Name |
Optogenetic investigate the cellular E/I balance hypothesis in freely moving mammals
(Opto-EIB-FMM)
|
[1] | ||||
|
Photoreceptor (PR) |
||||||
| Cofactor | All-trans-Retinal (Trans-Retinal) | |||||
| Controlled Protein | Functional protein | Volvox channelrhodopsin-1 | ||||
| OS Application Information (1) | ||||||
|---|---|---|---|---|---|---|
| Mechanism of Action | Ion channel open | [ 1] | ||||
| Controlled Signal Pathway | Neuron E/I balance regulation | |||||
| Effect | Sensor | |||||
| Application | Optical control the excitation and inhibition balance for psychatric diseases such as autism and schizophrenia curity | |||||
| Current Intensity | 132 ± 12 pA | |||||
| Channel Type | Cation channel | |||||
| Light Information | Activation Wavelength | 543 ± 7 nm | ||||
| Process | Reversible | |||||
| Deactivation Wavelength | Dark | |||||
| Activation Time | 3 ms | |||||
| Deactivation Time | 132 ± 12 ms | |||||
| Light Intensity | 7.6 milliwatts per square miliimeter | |||||
| Expression Information | Expression Method | Transfection | ||||
| Cell Lines | Mouse medial prefrontal cortex | |||||