Details of the Optogenetic Tool | OPTICS

General Information of This Photoreceptor (PR)
PR ID	PR00307
PR Name	Phytochrome B tetramer (PhyBt)
Source of Species	Arabidopsis
Class	Phytochromes
UniProt ID	P14713
GenBank	NP_179469
PDB ID	4OUR
Sequence	MVSGVGGSGGGRGGGRGGEEEPSSSHTPNNRRGGEQAQSSGTKSLRPRSNTESMSKAIQQ YTVDARLHAVFEQSGESGKSFDYSQSLKTTTYGSSVPEQQITAYLSRIQRGGYIQPFGCM IAVDESSFRIIGYSENAREMLGIMPQSVPTLEKPEILAMGTDVRSLFTSSSSILLERAFV AREITLLNPVWIHSKNTGKPFYAILHRIDVGVVIDLEPARTEDPALSIAGAVQSQKLAVR AISQLQALPGGDIKLLCDTVVESVRDLTGYDRVMVYKFHEDEHGEVVAESKRDDLEPYIG LHYPATDIPQASRFLFKQNRVRMIVDCNATPVLVVQDDRLTQSMCLVGSTLRAPHGCHSQ YMANMGSIASLAMAVIINGNEDDGSNVASGRSSMRLWGLVVCHHTSSRCIPFPLRYACEF LMQAFGLQLNMELQLALQMSEKRVLRTQTLLCDMLLRDSPAGIVTQSPSIMDLVKCDGAA FLYHGKYYPLGVAPSEVQIKDVVEWLLANHADSTGLSTDSLGDAGYPGAAALGDAVCGMA VAYITKRDFLFWFRSHTAKEIKWGGAKHHPEDKDDGQRMHPRSSFQAFLEVVKSRSQPWE TAEMDAIHSLQLILRDSFKES
Components	Photoreceptor	Phytochrome B tetramer (PhyBt)
	Complementary Protein	Phytochrome interacting factor 6 (C9S/C10S/S37A) (PIFS=PIF6(C9S/C10S/S37A))				Detail Info
	Cofactor	Phycocyanobilin (PCB)				Detail Info
3D Structure
3D Structure	Click to Save PDB File

Complementary Protein Detail of This PR
Complementary Protein	Phytochrome interacting factor 6 (C9S/C10S/S37A) (PIFS=PIF6(C9S/C10S/S37A))
UniProt ID	Q8L5W7
Sequence	MMFLPTDYSSRLSDQEYMELVFENGQILAKGQRSNVALHNQRTKSIMDLYEAEYNEDFMK SIIHGGGGAITNLGDTQVVPQSHVAAAHETNMLESNKHVD

Cofactor Detail of This PR
Cofactor Name	Phycocyanobilin (PCB)
PubChem CID	5280816
Structure
Formula	C33H38N4O6
Molecular Weight	586.7

Optogenetic System (OS) Consisting of This PR

OS00543

OS Name: Optogenetic regulate ligand -T-cell receptor interaction system (Opto-ligand-TCR)

[1] , [2] , [3]

Functional protein: Phytochrome B

Recruited protein: T-cell receptor

OS00690

OS Name: Optogenetic T Cell Receptor controling system 1 (Opto-TCR 1)

[4]

Functional protein: Phytochrome B tetramer

Recruited protein: T-cell receptor

OS00691

OS Name: Optogenetic T Cell Receptor controling system 2 (Opto-TCR 2)

[4]

Functional protein: Phytochrome B tetramer

Recruited protein: T-cell receptor

OS00692

OS Name: Optogenetic T Cell Receptor controling system 3 (Opto-TCR 3)

[4]

Functional protein: Phytochrome B tetramer

Recruited protein: T-cell receptor

OS00693

OS Name: Optogenetic T Cell Receptor controling system 4 (Opto-TCR 4)

[4]

Functional protein: Phytochrome B tetramer

Recruited protein: T-cell receptor

OS00694

OS Name: Optogenetic T Cell Receptor controling system 5 (Opto-TCR 5)

[4]

Functional protein: Phytochrome B tetramer

Recruited protein: T-cell receptor

OS00544

OS Name: Optogenetic TrkA regulate system (Opto-TrkA)

[5]

Fusion protein: Tropomyosin receptor kinases A

OS00545

OS Name: Optogenetic TrkB regulate system (Opto-TrkB)

[5]

Fusion protein: Tropomyosin receptor kinases B

References

1	Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor
2	Optogenetic Tuning of Ligand Binding to The Human T cell Receptor Using The opto-ligand-TCR System
3	Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding
4	Engineering of an Optogenetic T Cell Receptor Compatible with Fluorescence-Based Readouts
5	Neurotrophin receptor tyrosine kinases regulated with near-infrared light