Details of the Optogenetic System
| General Information of This Optogenetic System (OS) | ||||||
|---|---|---|---|---|---|---|
| OS ID |
OS00694
|
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| OS Name |
Optogenetic T Cell Receptor controling system 5
(Opto-TCR 5)
|
[1] | ||||
|
Photoreceptor (PR) |
|
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| Complementary Protein | Phytochrome interacting factor 6 (C9S/C10S/S37A) (PIFS=PIF6(C9S/C10S/S37A)) | |||||
| Cofactor | Phycocyanobilin (PCB) | |||||
| Controlled Protein | Functional protein | Phytochrome B tetramer | ||||
| Recruited protein | T-cell receptor | |||||
| OS Application Information (1) | ||||||
|---|---|---|---|---|---|---|
| Mechanism of Action | PhyBt-PIFS heterodimerization | [ 1] | ||||
| Controlled Signal Pathway | T cell receptor (TCR) | |||||
| Effect | Activation | |||||
| Application | Controls T cell development and activation | |||||
| Note | PIFS is allowed to be transported more efficiently to the cell surface | |||||
| Light Information | Activation Wavelength | 630660 nm | ||||
| Process | Reversible | |||||
| Deactivation Wavelength | 740780 nm | |||||
| Activation Time | Minutes | |||||
| Deactivation Time | Minutes | |||||
| Expression Information | Expression Method | Transduction | ||||
| Cell Lines | Jurkat T cells | |||||