Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00300
PR Name Bacterial phytochrome photoreceptors 1 (Bphp1)
Source of Species Rhodopseudomonas palustris
Class Phytochromes
UniProt ID A0A161I5N6
GenBank 1569047741
PDB ID 5OY5
Sequence
MAGHASGSPAFGTADLSNCEREEIHLAGSIQPHGALLVVSEPDHRIIQASANAAEFLNLG
SVLGVPLAEIDGDLLIKILPHLDPTAEGMPVAVRCRIGNPSTEYDGLMHRPPEGGLIIEL
ERAGPPIDLSGTLAPALERIRTAGSLRALCDDTALLFQQCTGYDRVMVYRFDEQGHGEVF
SERHVPGLESYFGNRYPSSDIPQMARRLYERQRVRVLVDVSYQPVPLEPRLSPLTGRDLD
MSGCFLRSMSPIHLQYLKNMGVRATLVVSLVVGGKLWGLVACHHYLPRFMHFELRAICEL
LAEAIATRITALESFAQSQSELFVQRLEQRMIEAITREGDWRAAIFDTSQSILQPLHAAG
CALVYEDQIRTIGDVPSTQDVREIAGWLDRQPRAAVTSTASLGLDVPELAHLTRMASGVV
AAPISDHRGEFLMWFRPERVHTVTWGGDPKKPFTMGDTPADLSPRRSFAKWHQVVEGTSD
PWTAADLAAARTIGQTVADIVLQF
Components Photoreceptor Bacterial phytochrome photoreceptors 1 (Bphp1)
Complementary Protein Minimal BphP1-interacting module from PpsR2 with 17-kDa molecular mass (Q-PAS1)
Detail Info
Cofactor Biliverdin (BV)
Detail Info
3D Structure
Click to Save PDB File
Complementary Protein Detail of This PR
Complementary Protein Minimal BphP1-interacting module from PpsR2 with 17-kDa molecular mass (Q-PAS1)
UniProt ID Q6N9K7
Sequence
MASKSVHADITLLLDMEGVIREATLSPTMAAESVDGWLGRRWSDIAGAEGGDKVRRMVED
ARRSGISAFRQINQPFPSGVEIPIEFTTMLLGDRTGMIAVGKNMQAVTELHSRLIAAQQA
MERDYWRLRELETRYRLVFDAAADAVMIVSAGDMRIVEANRAAVNAISRVERGNDDLAGR
DFLAEVAAADRDAVRDMLAQVRQRGTALSVLVHLGRYDRAWMLRGSLMSSERRQVFLLHF
TPVTTTPAIDDVDDDAVLRGLIDRIPDGFVALDSEGVVRHANQAFLDLVQIGSKPAAVGR
SLGVWMGRPGADLSSLLTLLRRYKTVRLFQTTIRGELGTETEVEVSAVDGEDDQYIGVLM
RNVARRLDAADDHDALRQALGPISKQLGRSSLRKLVKNAVSIVEQHYVKEALLRSKGNRT
ATAELLGLSRQSLYAKLNSYGFDDKGVVASAADGAEGASDDAED
Cofactor Detail of This PR
Cofactor Name Biliverdin (BV)
PubChem CID 5280353
Structure
Formula C33H34N4O6
Molecular Weight 582.6
Optogenetic System (OS) Consisting of This PR
OS00520
OS Info
OS Name: Near-infrared light-controlled gene expression system (NIR-GE)
[1] , [2]
Recruited protein: Regulatory protein Gal4
Detail Info
Fusion protein: Virus protein 16
Detail Info
OS00519
OS Info
OS Name: NIR and blue light sensing system for control protein localization (IRIS)
[1] , [2]
Functional protein: Bacterial phytochrome photoreceptors 1
Detail Info
Recruited protein: LOV2 domain of Avena sativa Phototropin 1
Detail Info
OS00518
OS Info
OS Name: Photoactivated GAL4 by BphP1 system (PA-GAL4-BphP1)
[3]
Functional protein: Bacterial phytochrome photoreceptors 1
Detail Info
Recruited protein: Regulatory protein Gal4
Detail Info
OS00517
OS Info
OS Name: Photoactivated TetR by BphP1 system 2 (PA-TetR-BphP1-2)
[3]
Fusion protein: Tetracycline repressor protein class D
Detail Info
Recruited protein: Virus protein 16
Detail Info
References
1 Near-infrared light-controlled systems for gene transcription regulation, protein targeting and spectral multiplexing
2 Near-Infrared Light-Controlled Gene Expression and Protein Targeting in Neurons and Non-neuronal Cells
3 Near-infrared optogenetic pair for protein regulation and spectral multiplexing