General Information of This Photoreceptor (PR)
PR ID PR00092
PR Name LOV2 domain of circular permutants (cpLOV2)
Source of Species Circularly permuted from LOV2
Class LOV domain
Sequence
MTEHVRDAAEREGVMLIKKTAENIDEAAKELGGGSGGSGGGLATTLERIEKNFVITDPRL
PDNPIIFASDSFLQLTEYSREEILGRNCRFLQGPETDRATVRKIRDAIDNQTEVTVQLIN
YTKSGKKFWNLFHLQPMRDQKGDVQYFIGVQLDG
Components Photoreceptor LOV2 domain of circular permutants (cpLOV2)
Complementary Protein Engineered protein Zdk2 affibody (Zdk2)
Detail Info
Cofactor Flavin mononucleotide (FMN)
Detail Info
3D Structure
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Complementary Protein Detail of This PR
Complementary Protein Engineered protein Zdk2 affibody (Zdk2)
Sequence
GGSVDNKFNKEMLSARVEIYGLPNLNWGQRFAFISSLTDDPSQSANLLAEAKKLNDAQAP
K
Cofactor Detail of This PR
Cofactor Name Flavin mononucleotide (FMN)
PubChem CID 643976
Structure
Formula C17H21N4O9P
Molecular Weight 456.3
Optogenetic System (OS) Consisting of This PR
OS00200
OS Info
OS Name: LOV2 domain of circular permutants for optogenetic engneering 1 (CPLOV2-1)
[1]
Recruited protein: Engineered protein Zdk2 affibody
Functional protein: LOV2 domain of circular permutants
OS00201
OS Info
OS Name: Optogenetic controlled CAR-T cell signal system (OptoCAR)
[1]
Fusion protein: A bacterial SsrA peptide
Recruited protein: Immunoreceptor tyrosine-based activation motifs
References
1 Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering