Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00240
CP Name Phytochrome B (PhyB)
CP Type Functional protein
Common Name Phytochrome B (Protein LONG HYPOCOTYL 3) (Protein OUT OF PHASE 1)
Organism Arabidopsis thaliana (Mouse-ear cress)
UniProt ID P14713
UniProt Entry PHYB_ARATH
KEGG ath:AT2G18790
Function Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenetic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc. It also controls the expression of its own gene(s) in a negative feedback fashion. Involved in the flowering time regulation. Involved in light-regulated circadian phase control that triggers stomatal aperture, stomatal conductance, and CO(2) assimilation. Implicated in red light perception, and, to a lower extent, in blue light signaling. Regulates temperature responses by associating with the promoters of key target genes in a temperature-dependent manner and subsequently repressing their expression probably in a PIF4-dependent manner. Thermal timer that integrates temperature information over the course of the night.
Sequence
MVSGVGGSGGGRGGGRGGEEEPSSSHTPNNRRGGEQAQSSGTKSLRPRSNTESMSKAIQQ
YTVDARLHAVFEQSGESGKSFDYSQSLKTTTYGSSVPEQQITAYLSRIQRGGYIQPFGCM
IAVDESSFRIIGYSENAREMLGIMPQSVPTLEKPEILAMGTDVRSLFTSSSSILLERAFV
AREITLLNPVWIHSKNTGKPFYAILHRIDVGVVIDLEPARTEDPALSIAGAVQSQKLAVR
AISQLQALPGGDIKLLCDTVVESVRDLTGYDRVMVYKFHEDEHGEVVAESKRDDLEPYIG
LHYPATDIPQASRFLFKQNRVRMIVDCNATPVLVVQDDRLTQSMCLVGSTLRAPHGCHSQ
YMANMGSIASLAMAVIINGNEDDGSNVASGRSSMRLWGLVVCHHTSSRCIPFPLRYACEF
LMQAFGLQLNMELQLALQMSEKRVLRTQTLLCDMLLRDSPAGIVTQSPSIMDLVKCDGAA
FLYHGKYYPLGVAPSEVQIKDVVEWLLANHADSTGLSTDSLGDAGYPGAAALGDAVCGMA
VAYITKRDFLFWFRSHTAKEIKWGGAKHHPEDKDDGQRMHPRSSFQAFLEVVKSRSQPWE
TAEMDAIHSLQLILRDSFKES
Optogenetic System (OS) Controlling This CP
OS00527
OS Info
OS Name
Light-activated nuclear translocation of adeno-associated virus nanoparticles system 1
[1]
Photoreceptor (PR) Name
Phytochrome B (PhyB)
PR Info
Components
Photoreceptor
Phytochrome B (PhyB)
Complementary Protein
Phytochrome interacting factor 6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00528
OS Info
OS Name
Light-activated nuclear translocation of adeno-associated virus nanoparticles system 2
[1]
Photoreceptor (PR) Name
Phytochrome B (PhyB)
PR Info
Components
Photoreceptor
Phytochrome B (PhyB)
Complementary Protein
Phytochrome interacting factor 6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00533
OS Info
OS Name
Light-induced dimerization system 3
[2], [3]
Photoreceptor (PR) Name
Residue1-621 of Phytochrome B (PhyB (1-621))
PR Info
Components
Photoreceptor
Residue1-621 of Phytochrome B (PhyB (1-621))
Complementary Protein
Phytochrome interacting factor 3 (PIF3)
Cofactor
Phycocyanobilin (PCB)
OS00534
OS Info
OS Name
Light-induced dimerization system 4
[2], [3]
Photoreceptor (PR) Name
Residue1-621 of Phytochrome B (PhyB (1-621))
PR Info
Components
Photoreceptor
Residue1-621 of Phytochrome B (PhyB (1-621))
Complementary Protein
Phytochrome interacting factor 3 (PIF3)
Cofactor
Phycocyanobilin (PCB)
OS00600
OS Info
OS Name
Llight-inducible organelle-targeting system
[4]
Photoreceptor (PR) Name
Residue1-908 of Phytochrome B (PhyB (1-908))
PR Info
Components
Photoreceptor
Residue1-908 of Phytochrome B (PhyB (1-908))
Complementary Protein
Phytochrome interacting factor 6; PIF6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00542
OS Info
OS Name
Optogenetic bind and release biomolecules trap
[5]
Photoreceptor (PR) Name
Residue1-650 of Phytochrome B (PhyB (1-650))
PR Info
Components
Photoreceptor
Residue1-650 of Phytochrome B (PhyB (1-650))
Complementary Protein
Phytochrome interacting factor 6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00599
OS Info
OS Name
Optogenetic control nucleo/cytoplasmatic partitioning system
[6]
Photoreceptor (PR) Name
Residue1-908 of Phytochrome B (PhyB (1-908))
PR Info
Components
Photoreceptor
Residue1-908 of Phytochrome B (PhyB (1-908))
Complementary Protein
Phytochrome interacting factor 6; PIF6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00531
OS Info
OS Name
Optogenetic control protein location system based on PhyB
[7]
Photoreceptor (PR) Name
Residue1-621 of Phytochrome B (PhyB (1-621))
PR Info
Components
Photoreceptor
Residue1-621 of Phytochrome B (PhyB (1-621))
Complementary Protein
Phytochrome interacting factor 3 (PIF3)
Cofactor
Phycocyanobilin (PCB)
OS00530
OS Info
OS Name
Optogenetic control SOS activity system
[8]
Photoreceptor (PR) Name
Residue1-621 of Phytochrome B (PhyB (1-621))
PR Info
Components
Photoreceptor
Residue1-621 of Phytochrome B (PhyB (1-621))
Complementary Protein
Phytochrome interacting factor 3 (PIF3)
Cofactor
Phycocyanobilin (PCB)
OS00514
OS Info
OS Name
Optogenetic controlled SOS signaling system
[9]
Photoreceptor (PR) Name
Phytochrome B (PhyB)
PR Info
Components
Photoreceptor
Phytochrome B (PhyB)
Complementary Protein
Phytochrome interacting factor 3 (PIF3)
Cofactor
Phycocyanobilin (PCB)
OS00536
OS Info
OS Name
Optogenetic modify subcellular protein localization system
[10], [11]
Photoreceptor (PR) Name
Residue1-621 of Phytochrome B (PhyB (1-621))
PR Info
Components
Photoreceptor
Residue1-621 of Phytochrome B (PhyB (1-621))
Complementary Protein
Phytochrome interacting factor 6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00597
OS Info
OS Name
Optogenetic regulate Galpha activity system 1
[12]
Photoreceptor (PR) Name
Residue1-908 of Phytochrome B (PhyB (1-908))
PR Info
Components
Photoreceptor
Residue1-908 of Phytochrome B (PhyB (1-908))
Complementary Protein
Phytochrome interacting factor 6; PIF6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00541
OS Info
OS Name
Optogenetic-drived affinity purification system
[13]
Photoreceptor (PR) Name
Residue1-650 of Phytochrome B (PhyB (1-650))
PR Info
Components
Photoreceptor
Residue1-650 of Phytochrome B (PhyB (1-650))
Complementary Protein
Phytochrome interacting factor 6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00523
OS Info
OS Name
Optogenetically regulate membrane receptor-ligand pair system
[14]
Photoreceptor (PR) Name
Phytochrome B (PhyB)
PR Info
Components
Photoreceptor
Phytochrome B (PhyB)
Complementary Protein
Phytochrome interacting factor 6 (C9S/C10S/S37A) (PIF6(C9S/C10S/S37A))
Cofactor
Phycocyanobilin (PCB)
References
1 Light-Activated Nuclear Translocation of Adeno-Associated Virus Nanoparticles Using Phytochrome B for Enhanced, Tunable, and Spatially Programmable Gene Delivery
2 Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling
3 Improvement of Phycocyanobilin Synthesis for Genetically Encoded Phytochrome-Based Optogenetics
4 A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast
5 Generic and reversible opto-trapping of biomolecules
6 Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish
7 Deconstructing and repurposing the light-regulated interplay between Arabidopsis phytochromes and interacting factors
8 Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System
9 Multichromatic Control of Signaling Pathways in Mammalian Cells
10 Optogenetic Control of Subcellular Protein Location and Signaling in Vertebrate Embryos
11 Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo
12 Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems
13 Light-Controlled Affinity Purification of Protein Complexes Exemplified by the Resting ZAP70 Interactome
14 Optogenetic control of integrin-matrix interaction