Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00442
CP Name CreN means N terminal of Cre recombinase and CreC means C terminal of Cre recombinase (Cre)
CP Type Recruited protein
Common Name Recombinase cre
Organism Escherichia phage P1 (Bacteriophage P1)
UniProt ID P06956
UniProt Entry RECR_BPP1
KEGG vg:2777477
Function Catalyzes site-specific recombination between two 34-base-pair LOXP sites. Its role is to maintain the phage genome as a monomeric unit-copy plasmid in the lysogenic state.
Sequence
MSNLLTVHQNLPALPVDATSDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNN
RKWFPAEPEDVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRRI
RKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAYNTLLRIAEIARI
RVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVTKLVERWISVSGVADDPNNYLFC
RVRKNGVAAPSATSQLSTRALEGIFEATHRLIYGAKDDSGQRYLAWSGHSARVGAARDMA
RAGVSIPEIMQAGGWTNVNIVMNYIRNLDSETGAMVRLLEDGD
Optogenetic System (OS) Controlling This CP
OS00055
OS Info
OS Name
Brainbow-based live imaging system
[1]
Photoreceptor (PR) Name
Cryptochrome 2 (CRY2)
PR Info
Components
Photoreceptor
Cryptochrome 2 (CRY2)
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00279
OS Info
OS Name
Photoactivatable split-Cre recombinase optogenetic system
[2]
Photoreceptor (PR) Name
Negative Magnet (nMag)
PR Info
Components
Photoreceptor
Negative Magnet (nMag)
Complementary Protein
Positive Magnet (pMag)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00068
OS Info
OS Name
Second-generation photoactivatable Cre recombinase
[3]
Photoreceptor (PR) Name
Photolyase homology region of Cryptochromes 2 (L348F) (CRY2PHR (L348F))
PR Info
Components
Photoreceptor
Photolyase homology region of Cryptochromes 2 (L348F) (CRY2PHR (L348F))
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00278
OS Info
OS Name
Tamoxifen-gated photoactivatable split-Cre recombinase optogenetic system
[4]
Photoreceptor (PR) Name
Negative Magnet (nMag)
PR Info
Components
Photoreceptor
Negative Magnet (nMag)
Complementary Protein
Positive Magnet (pMag)
Cofactor
Flavin adenine dinucleotide (FAD)
References
1 Live imaging of multicolor-labeled cells in Drosophila
2 A photoactivatable Cre-loxP recombination system for optogenetic genome engineering
3 Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase
4 An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics