Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00431
CP Name Guanine nucleotide-binding protein G(q) subunit alpha (Galphaq)
CP Type Recruited protein
Common Name Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)
Organism Homo sapiens (Human)
UniProt ID P50148
UniProt Entry GNAQ_HUMAN
KEGG hsa:2776
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).
Sequence
MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMR
IIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEK
VSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVL
RVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQR
DAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
Optogenetic System (OS) Controlling This CP
OS00597
OS Info
OS Name
Optogenetic regulate Galpha activity system 1
[1]
Photoreceptor (PR) Name
Residue1-908 of Phytochrome B (PhyB (1-908))
PR Info
Components
Photoreceptor
Residue1-908 of Phytochrome B (PhyB (1-908))
Complementary Protein
Phytochrome interacting factor 6; PIF6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00280
OS Info
OS Name
Optogenetic regulate Galpha activity system 2
[1]
Photoreceptor (PR) Name
Negative Magnet (nMag)
PR Info
Components
Photoreceptor
Negative Magnet (nMag)
Complementary Protein
Positive Magnet (pMag)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00346
OS Info
OS Name
Optogenetic regulate Galpha activity system 3
[1]
Photoreceptor (PR) Name
Negative Magnet (nMag (C71S))
PR Info
Components
Photoreceptor
Negative Magnet (nMag (C71S))
Complementary Protein
Positive Magnet (pMag)
Cofactor
Flavin adenine dinucleotide (FAD)
References
1 Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems