Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00352
PR Name ChrimsonR (ChrimsonR)
Source of Species Synthetic construct
Class Opsin
GenBank AHH02126.1
Mutation Site K176R
Sequence
MAELISSATRSLFAAGGINPWPNPYHHEDMGCGGMTPTGECFSTEWWCDPSYGLSDAGYG
YCFVEATGGYLVVGVEKKQAWLHSRGTPGEKIGAQVCQWIAFSIAIALLTFYGFSAWKAT
CGWEEVYVCCVEVLFVTLEIFKEFSSPATVYLSTGNHAYCLRYFEWLLSCPVILITLSNL
SGLKNDYSKRTMGLIVSCVGMIVFGMAAGLATDWLKWLLYIVSCIYGGYMYFQAAKCYVE
ANHSVPKGHCRMVVKLMAYAYFASWGSYPILWAVGPEGLLKLSPYANSIGHSICDIIAKE
FWTFLAHHLRIKIHEHILIHGDIRKTTKMEIGGEEVEVEEFVEEEDEDTV
Components Photoreceptor ChrimsonR (ChrimsonR)
Cofactor All-trans-Retinal (Trans-Retinal)
Detail Info
3D Structure
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Cofactor Detail of This PR
Cofactor Name All-trans-Retinal (Trans-Retinal)
PubChem CID 638015
Structure
Formula C20H28O
Molecular Weight 284.4
Optogenetic System (OS) Consisting of This PR
OS00733
OS Info
OS Name: Multicolor optogenetics 3 (Opto-Multicolor 3)
[1]
Functional protein: ChrimsonR
Detail Info
OS00601
OS Info
OS Name: Optogenetic functional ultrasound imaging system (Opto-FUS)
[2]
Functional protein: Chrimson
Detail Info
OS00602
OS Info
OS Name: Optogenetic visual perception system (Opto-VP)
[3] , [4]
Functional protein: Chrimson
Detail Info
References
1 Practical considerations in an era of multicolor optogenetics
2 Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex
3 Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
4 Partial recovery of visual function in a blind patient after optogenetic therapy