Details of the Optogenetic System

General Information of This Optogenetic System (OS)
OS ID
OS00602
OS Name
Optogenetic visual perception system (Opto-VP)
 [1], [2]
Photoreceptor (PR)
PR Info
PR Name
ChrimsonR (ChrimsonR)
Source of Species
Synthetic construct
Class
Opsin
GenBank
AHH02126.1
Mutation Site
K176R
3D Structure
Components
Photoreceptor: ChrimsonR (ChrimsonR)
Cofactor: All-trans-Retinal (Trans-Retinal)
Cofactor All-trans-Retinal (Trans-Retinal)
Controlled Protein Functional protein Chrimson
Detail Info
OS Application Information (1)
Mechanism of Action Ion channel open [ 1] , [ 2]
Controlled Signal Pathway Visual formation
Effect Sensor
Application An efficient vector for vision restoration in patient with retinitis pigmentosa
Note ChrimsonR is K176R mutation from Chrimson and it's potential constract for restore vision in patient with retinitis pigmentosa
Current Intensity 88.7 ± 25.5 pA
Channel Type Cation channel
Light Information Activation Wavelength 600 nm
Activation Time Microseconds
Light Intensity 10^15 photons per square centimeter
Expression Information Expression Method Transfection
Cell Lines Macaques primate retinal ganglion cells
References
1 Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
2 Partial recovery of visual function in a blind patient after optogenetic therapy