Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00308
PR Name Bacteriophytochrome from Deinococcus radiodurans (DrBphP (1-506))
Source of Species Deinococcus radiodurans
Class Phytochromes
UniProt ID Q9RZA4
GenBank 134105080
PDB ID 6FHT
Sequence
MSRDPLPFFPPLYLGGPEITTENCEREPIHIPGSIQPHGALLTADGHSGEVLQMSLNAAT
FLGQEPTVLRGQTLAALLPEQWPALQAALPPGCPDALQYRATLDWPAAGHLSLTVHRVGE
LLILEFEPTEAWDSTGPHALRNAMFALESAPNLRALAEVATQTVRELTGFDRVMLYKFAP
DATGEVIAEARREGLHAFLGHRFPASDIPAQARALYTRHLLRLTADTRAAAVPLDPVLNP
QTNAPTPLGGAVLRATSPMHMQYLRNMGVGSSLSVSVVVGGQLWGLIACHHQTPYVLPPD
LRTTLEYLGRLLSLQVQVKEAADVAAFRQSLREHHARVALAAAHSLSPHDTLSDPALDLL
GLMRAGGLILRFEGRWQTLGEVPPAPAVDALLAWLETQPGALVQTDALGQLWPAGADLAP
SAAGLLAISVGEGWSECLVWLRPELRLEVAWGGATPDQAKDDLGPRHSFDTYLEEKRGYA
EPWHPGEIEEAQDLRDTLTGALGERL
Components Photoreceptor Bacteriophytochrome from Deinococcus radiodurans (DrBphP (1-506))
Cofactor Biliverdin (BV)
Detail Info
3D Structure
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Cofactor Detail of This PR
Cofactor Name Biliverdin (BV)
PubChem CID 5280353
Structure
Formula C33H34N4O6
Molecular Weight 582.6
Optogenetic System (OS) Consisting of This PR
OS00546
OS Info
OS Name: Light-activated phosphodiesterases (LAPD)
[1] , [2] , [3]
Fusion protein: cGMP-dependent 3',5'-cyclic phosphodiesterase
Detail Info
OS00547
OS Info
OS Name: Nanobody-based red light-induced dimerization 1 (NanoReD 1)
[4]
Functional protein: Cryptochrome-2
Detail Info
Recruited protein: Light-induced dimerization binder-3
Detail Info
OS00548
OS Info
OS Name: Nanobody-based red light-induced dimerization 2 (NanoReD 2)
[4]
Functional protein: Cryptochrome-2
Detail Info
Recruited protein: Light-induced dimerization binder-14
Detail Info
OS00549
OS Info
OS Name: Nanobody-based red light-induced dimerization 3 (NanoReD 3)
[4]
Functional protein: Cryptochrome-2
Detail Info
Recruited protein: Light-induced dimerization binder-3
Detail Info
OS00634
OS Info
OS Name: Optogenetic bispecific T-cell engagers (OptoBiTEs)
[5]
Fusion protein: Putative DNA binding protein
Detail Info
References
1 Revisiting and Redesigning Light-Activated Cyclic-Mononucleotide Phosphodiesterases
2 Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic applications
3 Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase
4 Creating Red Light-Switchable Protein Dimerization Systems as Genetically Encoded Actuators with High Specificity
5 Far-Red Light Triggered Production of Bispecific T Cell Engagers (BiTEs) from Engineered Cells for Antitumor Application