Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00435
CP Name Protein bicaudal D homolog 2 (BICD)
CP Type Recruited protein
Common Name Protein bicaudal D homolog 2 (Bic-D 2)
Organism Homo sapiens (Human)
UniProt ID Q8TD16
UniProt Entry BICD2_HUMAN
KEGG hsa:23299
Function Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex. Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity).
Sequence
MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ
FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE
LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD
YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL
EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV
NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA
GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE
DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA
LTEKVSLLEKASRQDRELLA
Optogenetic System (OS) Controlling This CP
OS00007
OS Info
OS Name
Optogenetic control of organelle transport system
[1], [2]
Photoreceptor (PR) Name
Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
PR Info
Components
Photoreceptor
Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00595
OS Info
OS Name
Optogenetic intracellular transport system 5
[3]
Photoreceptor (PR) Name
Residue1-908 of Phytochrome B (PhyB (1-908))
PR Info
Components
Photoreceptor
Residue1-908 of Phytochrome B (PhyB (1-908))
Complementary Protein
Phytochrome interacting factor 6; PIF6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00540
OS Info
OS Name
Optogenetic intracellular transport system 6
[3]
Photoreceptor (PR) Name
Residue1-650 of Phytochrome B (PhyB (1-650))
PR Info
Components
Photoreceptor
Residue1-650 of Phytochrome B (PhyB (1-650))
Complementary Protein
Phytochrome interacting factor 6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
References
1 Optogenetic control of molecular motors and organelle distributions in cells
2 Light moves mountains in the cell
3 A Phytochrome-Derived Photoswitch for Intracellular Transport