Details of the Optogenetic System

General Information of This Optogenetic System (OS)
OS ID
OS00045
OS Name
Optogenetic control receptor molecules concentrate at the postsynaptic density system 2 (Opto-PSD 2)
 [1]
Photoreceptor (PR)
PR Info
PR Name
Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
Source of Species
Arabidopsis thalino
Class
Cryptochromes
UniProt ID
Q96524
GenBank
NP_849588
PDB ID
6X24
3D Structure
Components
Photoreceptor: Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
Complementary Protein: Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor: Flavin adenine dinucleotide (FAD)
Complementary Protein Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor Flavin adenine dinucleotide (FAD)
Controlled Protein Recruited protein Cryptochrome-interacting basic-helix-loop-helix 1
Detail Info
Fusion protein Disks large homolog 4
Detail Info
OS Application Information (1)
Mechanism of Action CRY2PHR-CIB1 heterodimerization [ 1]
Controlled Signal Pathway Protein translocation
Effect Activation
Application Control molecular composition of the postsnaptic desity with light
Light Information Activation Wavelength 488 nm
Process Reversible
Deactivation Wavelength Dark
Activation Time 0.52 min
Deactivation Time 5.1 min
Expression Information Expression Method Transfection
Cell Lines Hippocampal neurons
References
1 Optogenetic Control of Synaptic Composition and Function