General Information of This Controlled Protein (CP)
CP ID CP00513
CP Name Helix-turn-helix (HTH) region of the PLC3 (I860A, 27-mer) (dHTH)
CP Type Recruited protein
Common Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Organism Homo sapiens (Human)
UniProt ID Q01970
UniProt Entry PLCB3_HUMAN
KEGG hsa:5331
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence
HQDYAEALANPIKHVSLMDQRARQLAA
Optogenetic System (OS) Controlling This CP
OS00652
OS Info
OS Name
Opto-dHTH, an optogenetic inhibitor to completely disrupt GqGTP-PLC interactions 5
[1]
Photoreceptor (PR) Name
Improved Light-Inducible Dimer (iLID)
PR Info
Components
Photoreceptor
Improved Light-Inducible Dimer (iLID)
Complementary Protein
Stringent starvation protein B (SspB)
Cofactor
Flavin mononucleotide (FMN)
References
1 Spatiotemporal Optical Control of Gq-PLC Interactions