| General Information of This Controlled Protein (CP) |
| CP ID |
CP00425
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| CP Name |
Stringent starvation protein B (SspB) |
| CP Type |
Recruited protein
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| Common Name |
Stringent starvation protein B (Adapter protein SspB) (Specificity-enhancing factor SspB)
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| Organism |
Escherichia coli (strain K12)
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| UniProt ID |
P0AFZ3
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| UniProt Entry |
SSPB_ECOLI
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| KEGG |
ecj:JW3197; eco:b3228
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| Function |
Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth.; Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion.
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| Sequence |
MDLSQLTPRRPYLLRAFYEWLLDNQLTPHLVVDVTLPGVQVPMEYARDGQIVLNIAPRAV
GNLELANDEVRFNARFGGIPRQVSVPLAAVLAIYARENGAGTMFEPEAAYDEDTSIMNDE
EASADNETVMSVIDGDKPDHDDDTHPDDEPPQPPRGGRPALRVVK
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