Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00313
CP Name Tetracycline repressor protein class D (TetR)
CP Type Fusion protein
Common Name Tetracycline repressor protein class D
Organism Escherichia coli
UniProt ID P0ACT4
UniProt Entry TETR4_ECOLX
Function TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
Sequence
MARLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEIL
ARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFM
TENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPAAPDENLPPLLREALQIMDSD
DGEQAFLHGLESLIRGFEVQLTALLQIVGGDKLIIPFC
Optogenetic System (OS) Controlling This CP
OS00598
OS Info
OS Name
Optogenetic activate gene expression system
[1]
Photoreceptor (PR) Name
Residue1-908 of Phytochrome B (PhyB (1-908))
PR Info
Components
Photoreceptor
Residue1-908 of Phytochrome B (PhyB (1-908))
Complementary Protein
Phytochrome interacting factor 6; PIF6 (PIF6)
Cofactor
Phycocyanobilin (PCB)
OS00605
OS Info
OS Name
Optogenetic control gene expression by green light
[2]
Photoreceptor (PR) Name
Cobalamin-binding domain from Thermus thermophilus (TtCBD)
PR Info
Components
Photoreceptor
Cobalamin-binding domain from Thermus thermophilus (TtCBD)
Cofactor
5-deoxyadenosylcobalamin (AdoCbl)
OS00521
OS Info
OS Name
Photoactivated TetR by BphP1 system 1
[3]
Photoreceptor (PR) Name
Bacterial phytochrome photoreceptors 1 (Bphp1)
PR Info
Components
Photoreceptor
Bacterial phytochrome photoreceptors 1 (Bphp1)
Complementary Protein
Transcriptional regulator PpsR2 (PpsR2)
Cofactor
Biliverdin (BV)
OS00517
OS Info
OS Name
Photoactivated TetR by BphP1 system 2
[3]
Photoreceptor (PR) Name
Bacterial phytochrome photoreceptors 1 (Bphp1)
PR Info
Components
Photoreceptor
Bacterial phytochrome photoreceptors 1 (Bphp1)
Complementary Protein
Minimal BphP1-interacting module from PpsR2 with 17-kDa molecular mass (Q-PAS1)
Cofactor
Biliverdin (BV)
References
1 Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish
2 Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes
3 Near-infrared optogenetic pair for protein regulation and spectral multiplexing