Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00301
PR Name Bacterial phytochrome photoreceptors 1 (Bphp1)
Source of Species Rhodopseudomonas palustris
Class Phytochromes
UniProt ID A0A161I5N6
GenBank 1569047741
PDB ID 5OY5
Sequence
MAGHASGSPAFGTADLSNCEREEIHLAGSIQPHGALLVVSEPDHRIIQASANAAEFLNLG
SVLGVPLAEIDGDLLIKILPHLDPTAEGMPVAVRCRIGNPSTEYDGLMHRPPEGGLIIEL
ERAGPPIDLSGTLAPALERIRTAGSLRALCDDTALLFQQCTGYDRVMVYRFDEQGHGEVF
SERHVPGLESYFGNRYPSSDIPQMARRLYERQRVRVLVDVSYQPVPLEPRLSPLTGRDLD
MSGCFLRSMSPIHLQYLKNMGVRATLVVSLVVGGKLWGLVACHHYLPRFMHFELRAICEL
LAEAIATRITALESFAQSQSELFVQRLEQRMIEAITREGDWRAAIFDTSQSILQPLHAAG
CALVYEDQIRTIGDVPSTQDVREIAGWLDRQPRAAVTSTASLGLDVPELAHLTRMASGVV
AAPISDHRGEFLMWFRPERVHTVTWGGDPKKPFTMGDTPADLSPRRSFAKWHQVVEGTSD
PWTAADLAAARTIGQTVADIVLQF
Components Photoreceptor Bacterial phytochrome photoreceptors 1 (Bphp1)
Complementary Protein Transcriptional regulator PpsR2 (PpsR2)
Detail Info
Cofactor Biliverdin (BV)
Detail Info
3D Structure
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Complementary Protein Detail of This PR
Complementary Protein Transcriptional regulator PpsR2 (PpsR2)
UniProt ID Q6N9K7
Sequence
MASKSVHADITLLLDMEGVIREATLSPTMAAESVDGWLGRRWSDIAGAEGGDKVRRMVED
ARRSGISAFRQINQPFPSGVEIPIEFTTMLLGDRTGMIAVGKNMQAVTELHSRLIAAQQA
MERDYWRLRELETRYRLVFDAAADAVMIVSAGDMRIVEANRAAVNAISRVERGNDDLAGR
DFLAEVAAADRDAVRDMLAQVRQRGTALSVLVHLGRYDRAWMLRGSLMSSERRQVFLLHF
TPVTTTPAIDDVDDDAVLRGLIDRIPDGFVALDSEGVVRHANQAFLDLVQIGSKPAAVGR
SLGVWMGRPGADLSSLLTLLRRYKTVRLFQTTIRGELGTETEVEVSAVDGEDDQYIGVLM
RNVARRLDAADDHDALRQALGPISKQLGRSSLRKLVKNAVSIVEQHYVKEALLRSKGNRT
ATAELLGLSRQSLYAKLNSYGFDDKGVVASAADGAEGASDDAED
Cofactor Detail of This PR
Cofactor Name Biliverdin (BV)
PubChem CID 5280353
Structure
Formula C33H34N4O6
Molecular Weight 582.6
Optogenetic System (OS) Consisting of This PR
OS00522
OS Info
OS Name: Optogenetic control protein location system based on BphP1 (Opto-CPL-BphP1)
[1]
Fusion protein: Intersectin (ITSN) guanine exchange factor (GEF) catalytic domain
Detail Info
Recruited protein: Transcriptional regulator PpsR2
Detail Info
OS00521
OS Info
OS Name: Photoactivated TetR by BphP1 system 1 (PA-TetR-BphP1-1)
[2]
Fusion protein: Tetracycline repressor protein class D
Detail Info
Recruited protein: Virus protein 16
Detail Info
References
1 A bacterial phytochrome-based optogenetic system controllable with near-infrared light
2 Near-infrared optogenetic pair for protein regulation and spectral multiplexing