Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00355
PR Name Opto-1AR (Opto-1AR)
Source of Species synthetic construct
Class Opsin
Sequence
MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLY
VVACHRHLHSVLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLG
GEIALWSLVVLAIERYVVVSYPLRYPTIVTQRRAIMGVAFTWVMALACAAPPLVGWSRYI
PEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGRVYVVAKRESRGLKS
GLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAARMVIIMVIA
FLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRKAFQNV
LRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFF
SSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLS
ENGEEVTETSQVAPA
Components Photoreceptor Opto-1AR (Opto-1AR)
Cofactor All-trans-Retinal (Trans-Retinal)
Detail Info
3D Structure
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Cofactor Detail of This PR
Cofactor Name All-trans-Retinal (Trans-Retinal)
PubChem CID 638015
Structure
Formula C20H28O
Molecular Weight 284.4
Optogenetic System (OS) Consisting of This PR
OS00704
OS Info
OS Name: Opto-Gq-type GPCR Opto1AR (Astro-Opto1AR)
[1] , [2]
Functional protein: Opto-a1AR
Detail Info
OS00606
OS Info
OS Name: Optogenetic regulate hippocampal astrocytes system (OptoRHA)
[3] , [4]
Functional protein: Opto-a1AR
Detail Info
References
1 Astrocytic GPCR-Induced Ca2+Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes
2 Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement
3 Optogenetic Activation of Astrocytes-Effects on Neuronal Network Function
4 Temporally precise in vivo control of intracellular signalling