Details of the Optogenetic System

General Information of This Optogenetic System (OS)
OS ID
OS00704
OS Name
Opto-Gq-type GPCR Opto1AR (Astro-Opto1AR)
 [1], [2]
Photoreceptor (PR)
PR Info
PR Name
Opto-1AR (Opto-1AR)
Source of Species
synthetic construct
Class
Opsin
3D Structure
Components
Photoreceptor: Opto-1AR (Opto-1AR)
Cofactor: All-trans-Retinal (Trans-Retinal)
Cofactor All-trans-Retinal (Trans-Retinal)
Controlled Protein Functional protein Opto-a1AR
Detail Info
OS Application Information (1)
Mechanism of Action Ion channel open [ 1] , [ 2]
Controlled Signal Pathway Activation of Gq-type G protein-coupled receptors (GPCRs)
Effect Activation
Application Cytosolic Ca2+ elevations
Note Astrocytic GPCR-induced Ca2+ signaling is not causally related to local cerebral blood flow changes
Light Information Activation Wavelength 465 nm
Process Reversible
Deactivation Wavelength Dark
Activation Time 1 s
Light Intensity 1 miliwatts
Expression Information Expression Method Transgene
Cell Lines Mice astrocytes
References
1 Astrocytic GPCR-Induced Ca2+Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes
2 Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement