Details of the Optogenetic System

General Information of This Optogenetic System (OS)
OS ID
OS00606
OS Name
Optogenetic regulate hippocampal astrocytes system (OptoRHA)
 [1], [2]
Photoreceptor (PR)
PR Info
PR Name
Opto-1AR (Opto-1AR)
Source of Species
synthetic construct
Class
Opsin
3D Structure
Components
Photoreceptor: Opto-1AR (Opto-1AR)
Cofactor: All-trans-Retinal (Trans-Retinal)
Cofactor All-trans-Retinal (Trans-Retinal)
Controlled Protein Functional protein Opto-a1AR
Detail Info
OS Application Information (1)
Mechanism of Action Ion channel open [ 1] , [ 2]
Controlled Signal Pathway Glutamate and gliotransmitters synthesis
Effect Activation
Application Potentially be used to normalize the synaptic transmission and plasticity defects in a variety of neuropathological conditions
Note Opto-a1AR is a metabotropic opsin which can potentially be used to treat Alzheimers disease and other neurodegenerative disorders
Light Information Activation Wavelength 473 nm
Activation Time 1 s
Light Intensity 35 miliwatts per square milimeter
Expression Information Expression Method Transfection
Cell Lines Mouse astrocytes
References
1 Optogenetic Activation of Astrocytes-Effects on Neuronal Network Function
2 Temporally precise in vivo control of intracellular signalling