Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00126
PR Name LOV4 domain from Botrytis cinerea (BcLOV4)
Source of Species Botrytis cinerea
Class LOV domain
GenBank CCD53251.1
Sequence
MTDAIDHYYQNRDGPPSRSFSDEYDSYNKTAPLPPLSACPERAQTPNSKRIPITPNSAKS
TSESPRRITFSRDAGSSTKGSTQTSPSNQGSVSSRNGSNGNGLGLSSAGNFADFFSSEVF
YIVLHNPTTAHRFLKFCQSRACSENLEFLQKIDEYNRLIDEATRLLSTIYSTYVSSEAPK
QINISNSHARRLSHDIKGATHNVLPGLEDIFNGSQEQIEKLLASDLYPRFVKHQVTASAT
MALANDKERYPGLGDCFCLTDPRRADNPIVFASDGFVSVTGYSRSDIIPRNCRFLQGSFT
DRQATKRLRTSIENREETVELLLNYRKNGDPFWNLLYVSPLLDGNGDVRFFLGGQINCST
TIHSRTDVLRILSLNDEDTGSFIEGSNKTPSVRSKESNNASNYGKTSFFKSFKKYKANTV
EIRDEAGMEGELIDRIGKLQFKTQVEEFYTAYSKYLVLSYQPQSQNLIVKYFSPGIVDML
NLNMPNGLVAPIVDKDIFKVLTEHSPSSVPRTFKNVVREGIKAGRAVSVETGLLTGIEEI
KKSQNIFSGTTANRERGWKKAEEKYVCHFTPCKDEMGRVGWVVLTVAPKLERF
Components Photoreceptor LOV4 domain from Botrytis cinerea (BcLOV4)
Cofactor Flavin mononucleotide (FMN)
Detail Info
3D Structure
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Cofactor Detail of This PR
Cofactor Name Flavin mononucleotide (FMN)
PubChem CID 643976
Structure
Formula C17H21N4O9P
Molecular Weight 456.3
Optogenetic System (OS) Consisting of This PR
OS00247
OS Info
OS Name: Light regulated membrane location system (LRML)
[1]
Functional protein: LOV4 domain from Botrytis cinerea
Detail Info
OS00248
OS Info
OS Name: Optogenetic control Rac1 system (Opto-Rac1)
[2]
Fusion protein: Ras-related C3 botulinum substrate1
Detail Info
OS00709
OS Info
OS Name: Optogenetics of LOV domains with chemiluminescence 1 (Opto-chemilu 1)
[3]
Functional protein: LOV4 domain from Botrytis cinerea
Detail Info
References
1 Directly light-regulated binding of RGS-LOV photoreceptors to anionic membrane phospholipids
2 Optogenetic Rac1 engineered from membrane lipid-binding RGS-LOV for inducible lamellipodia formation
3 Photoactivation of LOV domains with chemiluminescence