Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00551
CP Name Transmembrane protein 198 (TMEM198)
CP Type Recruited protein
Common Name Transmembrane protein 198
Organism Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
UniProt ID Q6DFQ7
UniProt Entry TM198_XENTR
KEGG xtr:448513
Function Promotes lrp6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of lrp6 further enhancing its activity. Required for neural crest formation.
Sequence
MLQNIDNRTVDTGQDDPFDGFCSLESERHYDVVPTVVCSLCCLFGLVYTFFGYRCFKAIM
FLSGLLAGSAVIFLLCYKERIMDTQLSLELSAGIALGIGLLCGLVTMLVHSVGLFMTGLL
LGLLLAIASLVGLEQFYHPPSAWIPVGLMMGSAMLFAVLTLQWQKLFTVVSTATFGAAIL
TVCTDYFIELMLLVQYVYDRLRLETSHPLCWYSWVILGMWPVLSVLGIVVQWKLTAEGFS
HTDVIISRRQKRLQLLRIRQKDAKKRQNVASQEGTYRRKANPMKRYTGDILAPSYLQSLR
ERQTGTGTSMSSLSTNMQTIVDMDYECGSTVPLTATTPVIHV
Optogenetic System (OS) Controlling This CP
OS00730
OS Info
OS Name
Optogenetic activation of LRP6 system
[1], [2]
Photoreceptor (PR) Name
Cryptochrome 2 (CRY2)
PR Info
Components
Photoreceptor
Cryptochrome 2 (CRY2)
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
References
1 Activation of Wnt/-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease
2 Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development