| General Information of This Controlled Protein (CP) |
| CP ID |
CP00480
|
| CP Name |
Heme-responsive zinc finger transcription factor HAP1 (Hap1p) |
| CP Type |
Fusion protein
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| Common Name |
Heme-responsive zinc finger transcription factor HAP1 (CYP1 activatory protein) (Heme activator protein 1)
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| Organism |
Saccharomyces cerevisiae (Baker's yeast)
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| UniProt ID |
P0CS82
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| UniProt Entry |
HAP1_YEASX
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| Function |
Regulation of oxygen dependent gene expression. It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c. In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes. Binds to the sequence 5'-CGGNNNTNNCGG-3'. Is non-functional in terms of iso-1 cytochrome c expression in strain S288c and its derivatives.
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| Sequence |
SSNSPPLHMSSDSSKIKRKRNRIPLSCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYME
QTWAEEAEKELLKDNELKKLRERVKSLEKTLSKVHSSPSSNSLKSYNTPESSNLFMGSDE
HTTLVNANTGSASSASHMHQQQQQQQQQEQ
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