| General Information of This Controlled Protein (CP) |
| CP ID |
CP00324
|
| CP Name |
A single-pass transmembrane protein (Mid2) |
| CP Type |
Fusion protein
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| Common Name |
Cell wall integrity sensor MID2 (Mating pheromone-induced death protein 2) (Protein kinase A interference protein 1) (Serine-rich multicopy suppressor protein 1)
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| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
|
| UniProt ID |
P36027
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| UniProt Entry |
MID2_YEAST
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| KEGG |
sce:YLR332W
|
| Function |
Cell wall stress sensor. Involved in activation of a response that includes both stress-related increased chitin synthesis and the MPK1 mitogen-activated protein kinase cell integrity pathway. High-copy activator of the SKN7 transcription factor. Required during induction of MPK1 tyrosine phosphorylation under a variety of stress conditions. Required for PKC pathway activation under low pH conditions. Required for cell integrity signaling during pheromone-induced morphogenesis. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1 in cell wall integrity signaling.
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| Sequence |
MLSFTTKNSFRLLLLILSCISTIRAQFFVQSSSSNSSAVSTARSSVSRVSSSSSILSSSM
VSSSSADSSSLTSSTSSRSLVSHTSSSTSIASISFTSFSFSSDSSTSSSSSASSDSSSSS
SFSISSTSATSESSTSSTQTSTSSSSSLSSTPSSSSSPSTITSAPSTSSTPSTTAYNQGS
TITSIINGKTILSNHYTTVTYTPSATADSSNKSKSSGLSKKNRNIVIGCVVGIGVPLILV
ILALIYMFCIQSSRTDFIDSDGKVVTAYRANKFTKWWYMLLGKKVSDEYHSDSPLGGSAS
SAGGLDLDEADDVMEQSSLFDVRIRDSDSVLPNANTADHNNTNSGGEPINSSVASNDIIE
EKFYDEQGNELSPRNY
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