Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00095
PR Name LOV2 domain of circular permutants (I539E) (cpLOV2 (I539E))
Source of Species Circularly permuted from LOV2
Class LOV domain
Mutation Site I539E
Sequence
MTEHVRDAAEREGVMLIKKTAENEDEAAKELGGGSGGSGGGLATTLERIEKNFVITDPRL
PDNPIIFASDSFLQLTEYSREEILGRNCRFLQGPETDRATVRKIRDAIDNQTEVTVQLIN
YTKSGKKFWNLFHLQPMRDQKGDVQYFIGVQLDG
Components Photoreceptor LOV2 domain of circular permutants (I539E) (cpLOV2 (I539E))
Complementary Protein Stringent starvation protein B (SspB)
Detail Info
Cofactor Flavin mononucleotide (FMN)
Detail Info
3D Structure
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Complementary Protein Detail of This PR
Complementary Protein Stringent starvation protein B (SspB)
UniProt ID P0AFZ3
Sequence
MDLSQLTPRRPYLLRAFYEWLLDNQLTPHLVVDVTLPGVQVPMEYARDGQIVLNIAPRAV
GNLELANDEVRFNARFGGIPRQVSVPLAAVLAIYARENGAGTMFEPEAAYDEDTSIMNDE
EASADNETVMSVIDGDKPDHDDDTHPDDEPPQPPRGGRPALRVVK
Cofactor Detail of This PR
Cofactor Name Flavin mononucleotide (FMN)
PubChem CID 643976
Structure
Formula C17H21N4O9P
Molecular Weight 456.3
Optogenetic System (OS) Consisting of This PR
OS00204
OS Info
OS Name: Optical dimerizar ssrA-cpLOV2 (CpLID)
[1]
Fusion protein: A bacterial SsrA peptide
Detail Info
Functional protein: LOV2 domain of circular permutants
Detail Info
Recruited protein: Stringent starvation protein B
Detail Info
References
1 Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering