General Information of This Controlled Protein (CP)
CP ID CP00455
CP Name Transcription regulator LexA (LexA)
CP Type Recruited protein
Common Name Transcription regulator LexA (LexA-related repressor)
Organism Synechocystis sp. (strain PCC 6803 / Kazusa)
UniProt ID P73722
UniProt Entry LEXA_SYNY3
KEGG syn:sll1626
Function A probable transcription regulator, probably involved in carbon metabolism. Binds and probably regulates expression of bidirectional hydrogenase (hoxEFUHY), probably activates its transcription. A possible regulator of redox-responsive genes. Binds 2 direct repeats of the DNA with sequence 5'-CTA-N(9)-CTA-3' in the upstream region of both its own gene (includes the transcription start site) and crhR (includes the initiation codon) in a sequence-specific manner; does not bind crhR RNA. Binds to the crhR gene, represses its transcription.
Sequence
MEPLTRAQKELFDWLVSYIDETQHAPSIRQMMRAMNLRSPAPIQSRLERLRNKGYVDWTD
GKARTLRILHQKPKGVSVIGELKGGELVEADAEEVEKIDFAPLMKKSSVFALRVMSNDLV
DDFIVEGDMLILRSVTGEEEIEDGELVAASIKGGKIAIKRYYQDGTKVVLKASNNKGPGQ
ELKASDVEIQGILMGVWRNFQGV
Optogenetic System (OS) Controlling This CP
OS00029
OS Info
OS Name
Light inducible nuclear translocation and dimerization system
[1]
Photoreceptor (PR) Name
Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
PR Info
Components
Photoreceptor
Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
References
1 Engineering light-controllable CAR T cells for cancer immunotherapy