Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00448
CP Name Rho guanine nucleotide exchange factor 12 (LARG-DH)
CP Type Recruited protein
Common Name Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
Organism Homo sapiens (Human)
UniProt ID Q9NZN5
UniProt Entry ARHGC_HUMAN
KEGG hsa:23365
Function May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Sequence
PPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSP
SELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAA
TFCSNQPFALEMIKRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDN
IAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQR
Optogenetic System (OS) Controlling This CP
OS00191
OS Info
OS Name
Optogenetic control RhoA system
[1], [2]
Photoreceptor (PR) Name
Improved Light-Inducible Dimer (iLID)
PR Info
Components
Photoreceptor
Improved Light-Inducible Dimer (iLID)
Complementary Protein
Stringent starvation protein B (SspB)
Cofactor
Flavin mononucleotide (FMN)
References
1 Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling
2 Increasing spatial resolution of photoregulated GTPases through immobilized peripheral membrane proteins