Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00379
CP Name RNA polymerase (RNAP)
CP Type Fusion protein
Common Name DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (RNA polymerase subunit alpha) (Transcriptase subunit alpha)
Organism Escherichia coli (strain K12)
UniProt ID P0A7Z4
UniProt Entry RPOA_ECOLI
KEGG ecj:JW3257; eco:b3295
Function DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.
Sequence
MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVE
IDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGD
VEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPV
ERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQP
EVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSL
TEIKDVLASRGLSLGMRLENWPPASIADE
Optogenetic System (OS) Controlling This CP
OS00251
OS Info
OS Name
Blue light repressible promoter
[1]
Photoreceptor (PR) Name
Erythrobacter litoralis 222 amino acid protein (EL222)
PR Info
Components
Photoreceptor
Erythrobacter litoralis 222 amino acid protein (EL222)
Cofactor
Flavin mononucleotide (FMN)
References
1 Blue light-mediated transcriptional activation and repression of gene expression in bacteria