Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00321
CP Name Regulator of G-protein signaling 4 (RGS4)
CP Type Fusion protein
Common Name Regulator of G-protein signaling 4 (RGP4) (RGS4)
Organism Homo sapiens (Human)
UniProt ID P49798
UniProt Entry RGS4_HUMAN
KEGG hsa:5999
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
Sequence
MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWA
ESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFIS
VQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNP
SSCGAEKQKGAKSSADCASLVPQCA
Optogenetic System (OS) Controlling This CP
OS00035
OS Info
OS Name
Light-trigggered recruitment of G protein signaling protein system
[1]
Photoreceptor (PR) Name
Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
PR Info
Components
Photoreceptor
Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
References
1 Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration