Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00289
CP Name Wnt coreceptor LRP6 (LRP6c)
CP Type Fusion protein
Common Name La-related protein 6C (AtLARP6c)
Organism Arabidopsis thaliana (Mouse-ear cress)
UniProt ID Q9LHL3
UniProt Entry LRP6C_ARATH
KEGG ath:AT3G19090
Function Transcriptional regulator.
Sequence
MAQMQREEVESVTTEKKRLDGGGGSSGAQATAFKFNAQAPEFVPRSHTTAPAPQVSPVSG
YFYPCFHYNGGCIGGCGGGVCGGGGTGVGTQSSDWIYVGGGDPTAQHQHVHDPAAAFYIS
NPAVQFPASQNSSSSSKNLLSDDLRLKIVKQVEYQFTDMSLLANESISKHISKDPEGYVP
VSYIASTKKIKALTSNHHLVSLALRSSSKLVVSEDGKKVKRTSQFTDRDREELQGRTVVA
ENLPDDHSYQNLEKIFGVVGNVKAIRICHPPESNSSRPKGDFLMSNKIHALIEYDNTVIA
DKAVEKLNDERNWRKGLRVRLLLRCSPKSVLKNRRNFDGILIDDELPSYESGEDSPRLHL
TESQLDNDGDDNNVGGLWGKGRGKGRGRSPRSYAVGGGGRSFGIGLGVSLGIPSLGSHES
SSPKTATKGPRMPDGTRGFTMGRGKPSISLSPNNL
Optogenetic System (OS) Controlling This CP
OS00012
OS Info
OS Name
CRY2-mCherry-LRP6c with N mutated PPAP motifs
[1], [2], [3], [4]
Photoreceptor (PR) Name
Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
PR Info
Components
Photoreceptor
Photolyase homology region of Arabidopsis Cryptochromes 2 (CRY2PHR)
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
OS00730
OS Info
OS Name
Optogenetic activation of LRP6 system
[5], [6]
Photoreceptor (PR) Name
Cryptochrome 2 (CRY2)
PR Info
Components
Photoreceptor
Cryptochrome 2 (CRY2)
Complementary Protein
Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor
Flavin adenine dinucleotide (FAD)
References
1 CL6mN: Rationally Designed Optogenetic Photoswitches with Tunable Dissociation Dynamics
2 Optogenetic protein clustering and signaling activation in mammalian cells
3 Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2
4 Nucleation of the destruction complex on the centrosome accelerates degradation of -catenin and regulates Wnt signal transmission
5 Activation of Wnt/-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease
6 Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development