Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00309
PR Name Engineered high-potency photoactivated DGC (BphS)
Source of Species Rhodobacter sphaeroides
Class Phytochromes
Sequence
MARGCLMTISGGTFDPSICEMEPIATPGAIQPHGALMTARADSGRVAHASVNLGEILGLP
AASVLGAPIGEVIGRVNEILLREARRSGSETPETIGSFRRSDGQLLHLHAFQSGDYMCLD
IEPVRDEDGRLPPGARQSVIETFSSAMTQVELCELAVHGLQLVLGYDRVMAYRFGADGHG
EVIAERRRQDLEPYLGLHYPASDIPQIARALYLRQRVGAIADACYRPVPLLGHPELDDGK
PLDLTHSSLRSVSPVHLDYMQNMNTAASLTIGLADGDRLWGMLVCHNTTPRIAGPEWRAA
AGMIGQVVSLLLSRLGEVENAAETLARQSTLSTLVERLSTGDTLAAAFVAADQLILDLVG
ASAAVVRLAGQELHFGRTPPVDAMQKVLDSLGRPSPLEVLSLDDVTLRHPELPELLAAGS
GILLLPLTSGDGDLIAWFRPEHVQTITWGGNPAEHGTWNPATQRMRPRASFDAWKETVTG
RSLPWTSAERNCARELGEAIAAEMAQRTRAENCARELGEAIAAEMAQRTRAEELERVAMV
DSLTRLWNRLGIETLLKREWEYATRKNSPISIVMIDFDNFKQINDQHGHLVGDEVLQGSA
RLIISVLASYDILGRWGGDEFMLILPGSGREQTAVLLERIQATIAQNPVPTSAGPMAISL
SMGGVSVFTNQGEALQYWVEQADNQLMKVKRLGKGNFQLAEYHHHHHH
Components Photoreceptor Engineered high-potency photoactivated DGC (BphS)
Cofactor Biliverdin (BV)
Detail Info
3D Structure
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Cofactor Detail of This PR
Cofactor Name Biliverdin (BV)
PubChem CID 5280353
Structure
Formula C33H34N4O6
Molecular Weight 582.6
Optogenetic System (OS) Consisting of This PR
OS00550
OS Info
OS Name: Far-red light-induced split Cre-LoxP system (FISC)
[1]
Fusion protein: The bacterial c-di-GMP phosphodiesterase
Detail Info
References
1 A non-invasive far-red light-induced split-Cre recombinase system for controllable genome engineering in mice