Details of the Optogenetic Tool

General Information of This Photoreceptor (PR)
PR ID PR00012
PR Name Chromatic acclimation sensor (CcaS)
Source of Species Synechocystis.PCC 6803
Class Cyanobacteriochromes
UniProt ID Q06FY7
GenBank BAK51774.1
Sequence
MGKFLIPIEFVFLAIAMTCYLWHRQNQERRRIEISIKQQTQRERFINQITQHIRQSLNLE
TVLNTTVAEVKTLLQVDRVLIYRIWQDGTGSAITESVNANYPSILGRTFSDEVFPVEYHQ
AYTKGKVRAINDIDQDDIEICLADFVKQFGVKSKLVVPILQHNRASSLDNESEFPYLWGL
LITHQCAFTRPWQPWEVELMKQLANQVAIAIQQSELYEQLQQLNKDLENRVEKRTQQLAA
TNQSLRMEISERQKTEAALRHTNHTLQSLIAASPRGIFTLNLADQIQIWNPTAERIFGWT
ETEIIAHPELLTSNILLEDYQQFKQKVLSGMVSPSLELKCQKKDGSWIEIVLSAAPLLDS
EENIAGLVAVVADITEQKRQAEQIRLLQSVVVNTNDAVVITEAEPIDDPGPRILYVNEAF
TKITGYTAEEMLGKTPRVLQGPKTSRTELDRVRQAISQWQSVTVEVINYRKDGSEFWVEF
SLVPVANKTGFYTHWIAVQRDVTERRRTEEVRLALEREKELSRLKTRFFSMASHEFRTPL
STALAAAQLLENSEVAWLDPDKRSRNLHRIQNSVKNMVQLLDDILIINRAEAGKLEFNPN
WLDLKLLFQQFIEEIQLSVSDQYYFDFICSAQDTKALVDERLVRSILSNLLSNAIKYSPG
GGQIKIALSLDSEQIIFEVTDQGIGISPEDQKQIFEPFHRGKNVRNITGTGLGLMVAKKC
VDLHSGSILLKSAVDQGTTVTICLKRYNHLPRA
Components Photoreceptor Chromatic acclimation sensor (CcaS)
Complementary Protein Chromatic acclimation regulator (CcaR)
Detail Info
Cofactor Phycocyanobilin (PCB)
Detail Info
3D Structure
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Complementary Protein Detail of This PR
Complementary Protein Chromatic acclimation regulator (CcaR)
Sequence
MRILLVEDDLPLAETLAEALSDQLYTVDIATDASLAWDYASRLEYDLVILDVMLPELDGI
TLCQKWRSHSYLMPILMMTARDTINDKITGLDAGADDYVVKPVDLGELFARVRALLRRGC
ATCQPVLEWGPIRLDPSTYEVSYDNEVLSLTRKEYSILELLLRNGRRVLSRSMIIDSIWK
LESPPEEDTVKVHVRSLRQKLKSAGLSADAIETVHGIGYRLANLTEKSLCQGKN
Cofactor Detail of This PR
Cofactor Name Phycocyanobilin (PCB)
PubChem CID 5280816
Structure
Formula C33H38N4O6
Molecular Weight 586.7
Optogenetic System (OS) Consisting of This PR
OS00076
OS Info
OS Name: Light-switchable two-component system 1 (LSTCS 1)
[1] , [2]
Recruited protein: Chromatic acclimation regulator
Detail Info
Functional protein: Chromatic acclimation sensor
Detail Info
References
1 Refactoring and optimization of light-switchable Escherichia coli two-component systems
2 Multiple-Site Diversification of Regulatory Sequences Enables Interspecies Operability of Genetic Devices