Details of the Optogenetic System

General Information of This Optogenetic System (OS)
OS ID
OS00734
OS Name
Optogenetic activation of axons system (Opto-axons)
 [1]
Photoreceptor (PR)
PR Info
PR Name
Channelrhodopsin 2 (ChR2)
Source of Species
Chlamydomonas reinhardtii
Class
Opsin
UniProt ID
Q8RUT8
GenBank
1304111922
PDB ID
6EID
3D Structure
Components
Photoreceptor: Channelrhodopsin 2 (ChR2)
Cofactor: All-trans-Retinal (Trans-Retinal)
Cofactor All-trans-Retinal (Trans-Retinal)
Controlled Protein Functional protein Channelrhodopsin 2
Detail Info
OS Application Information (1)
Mechanism of Action Ion channel open [ 1]
Controlled Signal Pathway Release the neurotransmitter glutamate
Effect Activation
Application Activate neuron
Current Intensity 20 pA
Light Information Activation Wavelength 470 nm
Activation Time 10 ms
Expression Information Expression Method Injection
Cell Lines Mice
References
1 A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus