Details of the Optogenetic System

General Information of This Optogenetic System (OS)
OS ID
OS00705
OS Name
Optogenetic controling ventromedial orbitofrontal cortex system 1 (Opto-vmOFC 1)
 [1], [2]
Photoreceptor (PR)
PR Info
PR Name
Cryptochrome 2 (CRY2)
Source of Species
Arabidopsis thalino
Class
Cryptochromes
UniProt ID
Q96524
GenBank
NP_849588
PDB ID
6K8I
3D Structure
Components
Photoreceptor: Cryptochrome 2 (CRY2)
Complementary Protein: Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor: Flavin adenine dinucleotide (FAD)
Complementary Protein Cryptochrome-interacting basic-helix-loop-helix 1 (CIB1/CIBN)
Cofactor Flavin adenine dinucleotide (FAD)
Controlled Protein Functional protein Channelrhodopsin 2
Detail Info
OS Application Information (1)
Controlled Signal Pathway Ventromedial orbitofrontal cortex system
Effect Activation
Application Cause mice behavior performance impairments
Note VmOFC is a potential therapeutic target for decision-making deficits in patients with schizophrenia
Light Information Activation Wavelength 473 nm
Deactivation Wavelength Dark
Light Intensity 150-200 miliwatts
Expression Information Expression Method Injection
Cell Lines Wistar rats vmOFC glutamate cells
References
1 Postnatal Phencyclidine-Induced Deficits in Decision Making Are Ameliorated by Optogenetic Inhibition of Ventromedial Orbitofrontal Cortical Glutamate Neurons
2 The Translational Utility of Circuit-Based Manipulations in Preclinical Models