Details of the Optogenetic System
| General Information of This Optogenetic System (OS) | ||||||
|---|---|---|---|---|---|---|
| OS ID |
OS00610
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| OS Name |
Optogenetic stimulate Vglut2-positive neurons for Parkinson's Disease treatment system
(Opto-Vglut2-PD)
|
[1] | ||||
|
Photoreceptor (PR) |
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| Cofactor | All-trans-Retinal (Trans-Retinal) | |||||
| Controlled Protein | Functional protein | Channelrhodopsin 2 | ||||
| OS Application Information (1) | ||||||
|---|---|---|---|---|---|---|
| Mechanism of Action | Ion channel open | [ 1] | ||||
| Controlled Signal Pathway | Locomotor function | |||||
| Effect | Activation | |||||
| Application | Optotigenetic stimulate glutamatergic neurons of the cuneiform nucleus to improve locomotor activity in parkinsonian conditions | |||||
| Note | The experiment was carried out in mouse model, selective expression was achieved by Vglut2-positive neurons | |||||
| Channel Type | Cation Channel | |||||
| Light Information | Activation Wavelength | 470 nm | ||||
| Activation Time | 10 s | |||||
| Light Intensity | 41.2 miliwatts per fiber | |||||
| Expression Information | Expression Method | Transgene | ||||
| Cell Lines | Mouse CnF glutamatergic neurons | |||||