Details of the Optogenetic System
| General Information of This Optogenetic System (OS) | ||||||
|---|---|---|---|---|---|---|
| OS ID |
OS00301
|
|||||
| OS Name |
Optogenetic regulate cardiomyocytes system 1
(Opto-CM 1)
|
[1] | ||||
|
Photoreceptor (PR) |
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| Cofactor | All-trans-Retinal (Trans-Retinal) | |||||
| Controlled Protein | Functional protein | Channelrhodopsin 2 | ||||
| OS Application Information (1) | ||||||
|---|---|---|---|---|---|---|
| Mechanism of Action | Ion channel open | [ 1] | ||||
| Controlled Signal Pathway | Short and long QT syndromes regulation | |||||
| Effect | Inhibition | |||||
| Application | Prolongation or mild shortening of action potential duration | |||||
| Note | Modulate action potential properties in human CMs both in cellular and tissue level | |||||
| Channel Type | Cation channel | |||||
| Light Information | Activation Wavelength | 470 nm | ||||
| Process | Reversible | |||||
| Deactivation Wavelength | Dark | |||||
| Activation Time | 20 ms | |||||
| Deactivation Time | 30 ms | |||||
| Light Intensity | 1.3 milliwatts per square miliimeter | |||||
| Expression Information | Expression Method | Transgene | ||||
| Cell Lines | Human cardiomyocytes and pluripotent stem cells | |||||