Details of the Optogenetic System

General Information of This Optogenetic System (OS)
OS ID
OS00300
OS Name
Optogenetic neuromodulation for inflammation regulation system (Opto-NMF)
 [1]
Photoreceptor (PR)
PR Info
PR Name
Channelrhodopsin 2 (ChR2)
Source of Species
Chlamydomonas reinhardtii
Class
Opsin
UniProt ID
Q8RUT8
GenBank
1304111922
PDB ID
6EID
3D Structure
Components
Photoreceptor: Channelrhodopsin 2 (ChR2)
Cofactor: All-trans-Retinal (Trans-Retinal)
Cofactor All-trans-Retinal (Trans-Retinal)
Controlled Protein Functional protein Channelrhodopsin 2
Detail Info
OS Application Information (1)
Mechanism of Action Ion channel open [ 1]
Controlled Signal Pathway Inflammation initiates and amplifies
Effect Sensor
Application Optogenetic initiates and amplifies inflammation by activation of epineural
Note Offer reliable solutions for the neuromodulation of specific peripheral neurons
Current Intensity 11 mA
Channel Type Cation channel
Light Information Activation Wavelength 470 nm
Activation Time 10-20 ms
Light Intensity 91 milliwatts per square miliimeter
Expression Information Expression Method Transgene
Cell Lines Mouse axons
References
1 Epineural optogenetic activation of nociceptors initiates and amplifies inflammation