| General Information of This Controlled Protein (CP) |
| CP ID |
CP00372
|
| CP Name |
Paired amphipathic helix 1 (PAH1) |
| CP Type |
Fusion protein
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| Common Name |
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
|
| Organism |
Mus musculus (Mouse)
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| UniProt ID |
Q62141
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| UniProt Entry |
SIN3B_MOUSE
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| KEGG |
mmu:20467
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| Function |
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.
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| Sequence |
PVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLI
VGFNAFLPLGYRIDIPK
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