General Information of This Photoreceptor (PR)
PR ID PR00136
PR Name Channelrhodopsin 2 (C128S; D156A; T159C) (ChR2 (C128S; D156A; T159C))
Source of Species Chlamydomonas reinhardtii
Class Opsin
UniProt ID Q8RUT8
GenBank 1304111924
PDB ID 6EID
Mutation Site C128S; D156A; T159C
Sequence
MDYGGALSAVGRELLFVTNPVVVNGSVLVPEDQCYCAGWIESRGTNGAQTASNVLQWLAA
GFSILLLMFYAYQTWKSTCGWEEIYVCAIEMVKVILEFFFEFKNPSMLYLATGHRVQWLR
YAEWLLTSPVILIHLSNLTGLSNDYSRRTMGLLVSAIGCIVWGATSAMATGYVKVIFFCL
GLCYGANTFFHAAKAYIEGYHTVPKGRCRQVVTGMAWLFFVSWGMFPILFILGPEGFGVL
SVYGSTVGHTIIDLMSKNCWGLLGHYLRVLIHEHILIHGDIRKTTKLNIGGTEIEVETLV
EDEAEAGAVNKGTGK
Components Photoreceptor Channelrhodopsin 2 (C128S; D156A; T159C) (ChR2 (C128S; D156A; T159C))
Cofactor All-trans-Retinal (Trans-Retinal)
Detail Info
3D Structure
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Cofactor Detail of This PR
Cofactor Name All-trans-Retinal (Trans-Retinal)
PubChem CID 638015
Structure
Formula C20H28O
Molecular Weight 284.4
Optogenetic System (OS) Consisting of This PR
OS00282
OS Info
OS Name: Step-function opsin with ultra-high light sensitity (SOUL)
[1] , [2]
Functional protein: Channelrhodopsin 2
References
1 An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques
2 Light takes a deep dive