Details of the Controlled Protein

General Information of This Controlled Protein (CP)
CP ID CP00352
CP Name cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A)
CP Type Fusion protein
Common Name cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)
Organism Homo sapiens (Human)
UniProt ID O00408
UniProt Entry PDE2A_HUMAN
KEGG hsa:5138
Function cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration.
Sequence
GISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFT
YTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSV
SHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS
VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMA
EVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRP
MEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTI
RGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
Optogenetic System (OS) Controlling This CP
OS00546
OS Info
OS Name
Light-activated phosphodiesterases
[1], [2], [3]
Photoreceptor (PR) Name
Bacteriophytochrome from Deinococcus radiodurans (DrBphP (1-506))
PR Info
Components
Photoreceptor
Bacteriophytochrome from Deinococcus radiodurans (DrBphP (1-506))
Cofactor
Biliverdin (BV)
References
1 Revisiting and Redesigning Light-Activated Cyclic-Mononucleotide Phosphodiesterases
2 Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic applications
3 Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase